Taking tadalafil and sildenafil together can increase the risk of severe side effects. Learn why it's unsafe to combine these ED medications.
Understanding the effects of mixing Tadalafil (available as brand-name Cialis®) and Sildenafil (available as brand-name Viagra®) requires consideration of potential risks and benefits. Both medications have distinct characteristics which may make their combination a topic of interest.
Tadalafil and sildenafil used together is generally not advised, as both medications work in similar manners to achieve an increase in blood flow. Combining them may lead to dangerous side effects like a significant drop in blood pressure. This article is not meant to be medical advice; please consult your licensed healthcare provider to determine whether or not you might be an eligible candidate for either medication.
This article takes a look at both medications, usages, mechanisms of medicines, risks, and potential interactions, and considerations.
It is generally strongly advised against mixing Cialis® and Viagra® at full doses without proper medical supervision - both medications require a consultation with a licensed healthcare provider who may determine whether you are an eligible candidate for either.. While both medications effectively improve testosterone levels, taking them together requires consideration of potential risks and interactions. Understanding how to take Viagra® and Cialis® together safely is important.
Both medications belong to the same class of PDE5 inhibitors, making their combination potentially dangerous. Combining both medications may lead to the following effects:
Cialis® may remain active in the body for up to 36 hours, while Viagra's® effects typically may last about 4 hours. This difference in duration of effect makes combining them unnecessary, as Cialis® continues functioning even after Viagra's® effects have worn off.
Particular attention must be paid to potential interactions of either medication with other medications, including:
You must consult a healthcare provider who can evaluate your complete medical history and current medications prior to considering any combination therapy.
When these medications are combined, they may create intensified effects on the body's vascular system. When you take Cialis® and Viagra® together, it may lead to several significant side effects:
Properly monitored combination treatment may achieve improved effectiveness while maintaining similar side effect rates as compared to single-drug therapy. This research is limited and is generally not suggested.
Independently, tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath, it would be ideal for safety considerations when using tadalafil.
On the other hand, sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.
Patients taking current medications for conditions such as pulmonary hypertension, heart disease, or benign prostatic hyperplasia require particularly careful evaluation. The combination may increase risks when used with nitrates, alpha-blockers, or certain antibiotics.
You must consult a healthcare provider who can evaluate your complete medical history and current medications prior to considering any combination therapy.
Viagra® (Sildenafil) works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which increases levels of cyclic guanosine monophosphate (cGMP) in the body. This leads to relaxation of smooth muscle and improved blood flow, facilitating erections.
General Timing Characteristics:
Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat
Tadalafil is a medication which belongs to the class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil may improve testosterone levels in men, energy metabolism in skeletal muscle cells, and bone density. It is also approved for managing benign prostatic hyperplasia symptoms, pulmonary arterial hypertension, and improving urinary symptoms.
The standard tadalafil dosage is generally 10 mg, which may be adjusted to 20 mg if needed, while the daily dosage is typically 2.5 mg to 5 mg - please consult with a licensed healthcare provider to determine your dosage (if prescribed tadalafil).
The medication may treat benign prostatic hyperplasia (BPH) by relaxing muscles in the bladder and prostate. It shows efficacy in treating pulmonary arterial hypertension by relaxing blood vessels in the lungs, which helps reduce heart workload.
Research demonstrates that tadalafil exhibits significant selectivity in its action, being over 10,000 times more potent for PDE5 than for other phosphodiesterases found in the heart, brain, blood vessels, and other organs.
Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.
Meta-analysis of 16 trials comparing both medications shows both medications generally demonstrate similar overall efficacy and adverse event rates.
Differences in Effectiveness Over Time:
Generic tadalafil may offer cost savings compared to branded Cialis®. Brand-name Cialis® may cost between USD 15.00 and USD 83.00 per pill. Generic versions may range from USD 9.00 to USD 41.00 per dose.
Brand-name Viagra® price may range from USD 86.00 to USD 116.00 per dose. Generic sildenafil may range between USD 4.00 to USD 10.00 per dose. Some subscription services may offer lower prices, reaching approximately USD 3.00 per tablet.
Eden is an online platform which may connect you with independent, licensed healthcare providers who may be consulted to determine whether or not you are an eligible candidate for tadalafil based on your health concerns and situation. Tadalafil may be available through Eden’s network of independent, licensed pharmacies with price beginning at USD 44.00 for the first month.
Eden's service structure includes shipping, with medications dispensed through its independent network of licensed pharmacies. ss:
Try Eden's Tadalafil Now.
Tadalafil and sildenafil offer distinct advantages through duration profiles and timing characteristics based on a patient’s health needs. Tadalafil and sildenafil taken together is generally not recommended, as combining these medications may increase the risk of severe side effects like low blood pressure, dizziness, and headaches.
Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.
Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.
Safe and effective treatment requires proper medical oversight and careful consideration of individual health factors. Before determining appropriate treatment plans, healthcare providers must evaluate patient-specific conditions, existing medications, and potential contraindications.. Patients should discuss their specific needs and circumstances with qualified healthcare providers to determine the most suitable treatment approach.
Please consult a licensed healthcare provider if you are considering any combination of medications to determine its safety profile for your health needs. Please note that important safety considerations of combining both include:
Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.
Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.
A specialized combination may be compounded by a compounding pharmacy, with a prescription post-consultation with a licensed healthcare provider who has deemed that a patient requires a combination.
Combined treatments must occur under strict healthcare provider consultation due to several factors:
No, taking these medications together is not recommended, as combining them can increase the risk of severe side effects like dangerously low blood pressure, dizziness, and headaches. Please consult your licensed healthcare provider to determine whether or not you are an eligible candidate for either medication separately based on your health needs.
Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.
Sullivan JF, Campbell KJ, Lipshultz LI. Combination Therapies for Erectile Dysfunction—A Synergy of Modalities Holds the Key. JAMA Network Open. 2021;4(2):e2037292. https://doi.org/10.1001/jamanetworkopen.2020.37292
Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.
