Tadalafil And Sildenafil Together: What Are The Effects?

Should You/Can You Take Viagra® and Cialis® Together?

It is generally strongly advised against mixing Cialis® and Viagra® at full doses without proper medical supervision - both medications require a consultation with a licensed healthcare provider who may determine whether you are an eligible candidate for either.. While both medications effectively improve testosterone levels, taking them together requires consideration of potential risks and interactions. Understanding how to take Viagra® and Cialis® together safely is important. 

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Both medications belong to the same class of PDE5 inhibitors, making their combination potentially dangerous. Combining both medications may lead to the following effects: 

• Dangerous low blood pressure
• Increased risk of fainting
• Potential for priapism
• Severe chest pain
• Pronounced back pain
• Significant dizziness

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Cialis® may remain active in the body for up to 36 hours, while Viagra's® effects typically may last about 4 hours. This difference in duration of effect makes combining them unnecessary, as Cialis® continues functioning even after Viagra's® effects have worn off.

Particular attention must be paid to potential interactions of either medication with other medications, including:

• Nitrates and alpha-blockers
• Other ED medications
• Medications for pulmonary hypertension
• Heart disease treatments
• BPH medications

You must consult a healthcare provider who can evaluate your complete medical history and current medications prior to considering any combination therapy. 

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Tadalafil and Sildenafil Together: What are the Effects?

When these medications are combined, they may create intensified effects on the body's vascular system. When you take Cialis® and Viagra® together, it may lead to several significant side effects:

• Excessive blood pressure reduction
• Increased risk of dizziness and fainting
• Enhanced likelihood of headaches
• Greater chance of heart palpitations
• Potential for prolonged, painful erections

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Properly monitored combination treatment may achieve improved effectiveness while maintaining similar side effect rates as compared to single-drug therapy. This research is limited and is generally not suggested. 

Independently, tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath, it would be ideal for safety considerations when using tadalafil.

On the other hand, sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.

Patients taking current medications for conditions such as pulmonary hypertension, heart disease, or benign prostatic hyperplasia require particularly careful evaluation. The combination may increase risks when used with nitrates, alpha-blockers, or certain antibiotics.

You must consult a healthcare provider who can evaluate your complete medical history and current medications prior to considering any combination therapy. 

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How Viagra® (Sildenafil) Works

Sildenafil works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which increases levels of cyclic guanosine monophosphate (cGMP) in the body. This leads to relaxation of smooth muscle and improved blood flow, facilitating erections. 

General Timing Characteristics:

• Reaches maximum concentration within one hour [6]
• May begin working within 30 minutes [8]
• Effects may last up to 4 hours [8]
• Half-life of approximately 4 hours [8]

Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat

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How Cialis® (Tadalafil) Works

Tadalafil is a medication which belongs to the class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors. Tadalafil may improve testosterone levels in men, energy metabolism in skeletal muscle cells, and bone density. It is also approved for managing benign prostatic hyperplasia symptoms, pulmonary arterial hypertension, and improving urinary symptoms. 

The standard tadalafil dosage is generally 10 mg, which may be adjusted to 20 mg if needed, while the daily dosage is typically 2.5 mg to 5 mg - please consult with a licensed healthcare provider to determine your dosage (if prescribed tadalafil). 

The medication may treat benign prostatic hyperplasia (BPH) by relaxing muscles in the bladder and prostate. It shows efficacy in treating pulmonary arterial hypertension by relaxing blood vessels in the lungs, which helps reduce heart workload.

Research demonstrates that tadalafil exhibits significant selectivity in its action, being over 10,000 times more potent for PDE5 than for other phosphodiesterases found in the heart, brain, blood vessels, and other organs. 

Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.

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Is Tadalafil or Sildenafil Better?

Meta-analysis of 16 trials comparing both medications shows both medications generally demonstrate similar overall efficacy and adverse event rates.

Differences in Effectiveness Over Time:

• Tadalafil improves psychological outcomes compared to sildenafil
• Peak concentration occurs after two hours for tadalafil versus one hour for sildenafil 
• Tadalafil remains effective for up to 36 hours, while sildenafil lasts 4-6 hours
• Sildenafil's effectiveness may decrease after fatty meals, unlike tadalafil 

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Cost of Tadalafil

Generic tadalafil may offer cost savings compared to branded Cialis®. Brand-name Cialis® may cost between USD 15.00 and USD 83.00 per pill. Generic versions may range from USD 9.00 to USD 41.00 per dose.

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Cost of Sildenafil

Brand-name Viagra® price may range from USD 86.00 to USD 116.00 per dose. Generic sildenafil may range between USD 4.00 to USD 10.00 per dose. Some subscription services may offer lower prices, reaching approximately USD 3.00 per tablet.

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Tadalafil at Eden

Eden is an online platform which may connect you with independent, licensed healthcare providers who may be consulted to determine whether or not you are an eligible candidate for tadalafil based on your health concerns and situation. Tadalafil may be available through Eden’s network of independent, licensed pharmacies with price beginning  at USD 44.00 for the first month. 

Eden's service structure includes shipping, with medications dispensed through its independent network of licensed pharmacies. ss:

Try Eden's Tadalafil Now.

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Final Thoughts

Tadalafil and sildenafil offer distinct advantages through duration profiles and timing characteristics based on a patient’s health needs. Tadalafil and sildenafil taken together is generally not recommended, as combining these medications may increase the risk of severe side effects like low blood pressure, dizziness, and headaches.

Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.

Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.

Safe and effective treatment requires proper medical oversight and careful consideration of individual health factors. Before determining appropriate treatment plans, healthcare providers must evaluate patient-specific conditions, existing medications, and potential contraindications.. Patients should discuss their specific needs and circumstances with qualified healthcare providers to determine the most suitable treatment approach.

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FAQ

Can a low dose of Cialis® and Viagra® work together?

Please consult a licensed healthcare provider if you are considering any combination of medications to determine its safety profile for your health needs. Please note that important safety considerations of combining both include:

• Increased risk of adverse effects
• Potential low blood pressure complications
• Need for careful medical monitoring
• Specific dosing requirements

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Tadalafil may cause side effects such as headache, flushing, back pain, muscle aches, indigestion, and nasal congestion. Serious but rare side effects include sudden vision or hearing loss, priapism (prolonged erection), and symptoms of heart problems like chest pain or shortness of breath.

Sildenafil may cause side effects such as headache, flushing, nasal congestion, indigestion, dizziness, and vision changes (e.g., blurred vision or sensitivity to light). Rare but serious side effects include priapism (prolonged erection), sudden vision or hearing loss, and heart-related symptoms like chest pain or irregular heartbeat.

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Is there a pill that combines Viagra® and Cialis®?

A specialized combination may be compounded by a compounding pharmacy, with a prescription post-consultation with a licensed healthcare provider who has deemed that a patient requires a combination. 

Combined treatments must occur under strict healthcare provider consultation due to several factors:

• The combination is only available based on a healthcare provider’s determination that it is required for a patient based on their health needs
• Requires specialized dosing adjustments
• Necessitates regular monitoring
• Demands careful evaluation of existing medications

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Can I take tadalafil and sildenafil together?

No, taking these medications together is not recommended, as combining them can increase the risk of severe side effects like dangerously low blood pressure, dizziness, and headaches. Please consult your licensed healthcare provider to determine whether or not you are an eligible candidate for either medication separately based on your health needs. 

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Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

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References

1. Cui H, Liu B, Song Z, et al. Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2015;47(1):20-24. https://doi.org/10.1111/and.12216
   
   
2. Urologic Surgeons of WA–Privia Medical. Tadalafil (CIALIS) vs Sildenafil (Viagra): Is One Better? Published online June 7, 2023. Accessed December 10, 2024. https://www.dcurology.net/2023/06/07/comparing-tadalafil-generic-cialis-and-sildenafil-generic-viagra
   
   
3. Gong B, Ming Ma, Xie W, et al. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International urology and nephrology. 2017;49(10):1731-1740. https://doi.org/10.1007/s11255-017-1644-5
   
   
4. Ghosh PK. Chromosome heteromorphism in children with congenital malformation. Indian journal of experimental biology. 1979;17(11):1186-1189. Accessed December 10, 2024. https://www.ncbi.nlm.nih.gov/books/NBK549843
   
   
5. Neuzillet Y, Hupertan V, Cour F, Botto H, Lebret T. A randomized, double-blind, crossover, placebo-controlled comparative clinical trial of arginine aspartate plus adenosine monophosphate for the intermittent treatment of male erectile dysfunction. Andrology. 2013;1(2):223-228. https://doi.org/10.1111/j.2047-2927.2012.00046.x
   
   
6. AvKARE, Inc. SILDENAFIL- sildenafil tablet AvPAK. Accessed December 10, 2024. https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/e08de794-9b7e-aae6-9c89-a0c0d090cc76/spl-doc
7. Drug Bank. Tadalafil. Accessed December 10, 2024. https://go.drugbank.com/drugs/DB00820
   
   
8. Mayo Clinic. Tadalafil (oral route). Accessed December 10, 2024. https://www.mayoclinic.org/drugs-supplements/tadalafil-oral-route/description/drg-20067204
   
   
9. Food and Drug Administration. Questions and Answers for Cialis (tadalafil). Published online November 3, 2018. Accessed December 10, 2024. https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/questions-and-answers-cialis-tadalafil
   
   
10. Gong B, Ming Ma, Xie W, et al. Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis. International urology and nephrology. 2017;49(10):1731-1740. https://doi.org/10.1007/s11255-017-1644-5
    
    
11. GoodRX. Tadalafil (Cialis). Accessed December 10, 2024. https://www.goodrx.com/tadalafil-cialis
    
    
12. GoodRX. Viagra (Sildenafil). Accessed December 10, 2024. https://www.goodrx.com/viagra
    
    
13. Cui H, Liu B, Song Z, et al. Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction. Andrologia. 2014;47(1):20-24. https://doi.org/10.1111/and.12216
    
    

Sullivan JF, Campbell KJ, Lipshultz LI. Combination Therapies for Erectile Dysfunction—A Synergy of Modalities Holds the Key. JAMA Network Open. 2021;4(2):e2037292. https://doi.org/10.1001/jamanetworkopen.2020.37292