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Sermorelin vs. Semaglutide: Can You Take Them Both? (Benefits and Considerations)
Carson @ Eden
March 20, 2025
Last Updated:
Cardio + Strength
10 min read
Compare Sermorelin vs. Semaglutide: key differences, benefits, risks, and if they can be taken together. Explore expert insights and health considerations.
Sermorelin stimulates natural human growth hormone (HGH) production, supporting:some text
Muscle growth and preservation
Overall well-being and vitality
Compounded semaglutide functions as a glucagon-like peptide-1 GLP-1 receptor agonist, providing:
Improved insulin productionsome text
Reduced appetite
Enhanced blood sugar control
As more patients explore treatment options for weight management and metabolic health, questions about combining medications may arise. Either or both medications, if being considered, require that you consult a licensed healthcare provider who can determine whether or not you are a candidate for either treatment and if so approved, prescribe you for the treatment. This article includes a general understanding of compounded semaglutide and sermorelin and is not meant to be conclusive.
Sermorelin is a synthetic form of growth hormone-releasing hormone (GHRH), or a 29-amino acid peptide which functions by stimulating the pituitary gland’s natural production of human growth hormone. It may be used to diagnose and treat growth hormone deficiency in children in certain circumstances may be prescribed by a licensed healthcare provider to adults. The side effects of sermorelin may include injection site reactions (redness, swelling, or pain), headache, flushing, dizziness, nausea, fatigue, sleep disturbances, increased appetite, joint pain, and allergic reactions such as rash or difficulty breathing.
Sermorelin therapy is a hormone optimization therapy, functioning as a synthetic analog of growth hormone-releasing hormone (GHRH) which stimulates the body's natural hormone production mechanisms. This hormone works by binding to specific receptors in the brain, triggering the pituitary gland to release growth hormone
Used for treating growth hormone deficiency, sermorelin has shown success, with studies indicating improved growth rates in 74% of children after six months of treatment. The medication works by binding to specific receptors on the pituitary gland, effectively enhancing the body's natural hormone production processes.
It may be prescribed by a licensed healthcare provider in limited circumstances for adults.
Sermorelin dosage may typically include doses ranging from 200 to 300 mcg administered daily via subcutaneous injection, or as prescribed by a licensed healthcare provider. While how long sermorelin stays in your system is relatively short, with a half-life of 10-20 minutes, its effects on growth hormone release may last for several hours.
Does sermorelin increase appetite or does sermorelin make you hungry?
One side effect of sermorelin may be increased appetite - please consult your licensed healthcare provider to understand the effects of sermorelin.
What is compounded semaglutide?
Compounded semaglutide is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management. It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1). It is available in compounded form.
First approved by the FDA in 2017 and branded as Ozempic(R) for T2 diabetes control and WeGovy(R) for weight management, it may also be available as prescribed by a licensed healthcare provider as compounded semaglutide for type 2 diabetes and weight management. Compounded semaglutide contains the same active ingredient as the trademarked medications. Compounded semaglutide is not approved by the FDA for effectiveness, safety or quality.
Compounded semaglutide may be available with additional supplements such as B12 for enhanced benefits. The medication works through multiple mechanisms to achieve its therapeutic effects:
Increases insulin production when blood sugar is elevated
Reduces appetite through brain receptor activation
Slows gastric emptying for prolonged satiety
Suppresses glucagon release for better blood sugar control
Currently, semaglutide is available in three FDA-approved formulations: Wegovy® for weight loss, Ozempic® for diabetes control, and Rybelsus® as an oral option.
For optimal results, healthcare providers may prescribe compounded semaglutide as part of a personalized treatment plan which includes dietary modifications and regular physical activity.
Understanding how long it takes for compounded semaglutide to work is crucial for patient expectations. Most individuals may begin to notice weight loss effects over 8-12 weeks of starting treatment, with results typically observed over several months of consistent use.
Does compounded semaglutide affect hormones?
Compounded semaglutide may influence various hormonal systems in the body. While its primary action is on GLP-1 receptors, it may indirectly affect other hormones. Some patients report changes in their menstrual cycle, leading to questions about compounded semaglutide and periods. Women should discuss any menstrual irregularities with their healthcare provider.
How long does it take for compounded semaglutide to work?
The timeline for compounded semaglutide's effects can vary among individuals. Generally, patients may begin to notice changes in appetite and weight within 8-12 weeks of starting treatment as mentioned earlier.
Differences Between Sermorelin and compounded semaglutide
While both medications contribute to metabolic health, their fundamental mechanisms of action differ significantly. The primary distinction lies in their cellular targets and physiological effects on the body.
Compounded semaglutide may be available for management of T2 diabetes or weight management. Sermorelin may be available to treat growth hormone deficiency in children in certain circumstances may be prescribed by a licensed healthcare provider to adults. Sermorelin may support healthy growth hormone levels, muscle enhancement and overall well-being.
Differences between sermorelin vs compounded semaglutide include:
Mechanism of Action: Sermorelin stimulates natural human growth hormone (HGH) production from the pituitary gland, while compounded semaglutide mimics glucagon-like peptide-1 (GLP-1) to regulate blood sugar and appetite
Can Sermorelin and Compounded Semaglutide be Taken Together?
Anyone considering either or both medications must consult a licensed healthcare provider, who will evaluate their individual health needs and determine whether they may or may not be eligible for either or both medications.
Side Effects
Understanding potential risks and sermorelin side effects is crucial for patients considering combination therapy with sermorelin and compounded semaglutide.
The side effects of sermorelin may include injection site reactions (redness, swelling, or pain), headache, flushing, dizziness, nausea, fatigue, sleep disturbances, increased appetite, joint pain, and allergic reactions such as rash or difficulty breathing.
The side effects of compounded semaglutide include possible thyroid tumors, including cancer, pancreatitis, changes in vision, low blood sugar, kidney problems, and serious allergic reactions.
Other common side effects of both may include:
Gastrointestinal side effects:
Nausea and vomitingsome text
Diarrhea
Abdominal discomfort
Injection site reactions
Headaches
Fluid retention
More serious potential risks include pancreatic complications, diabetic retinopathy issues, and kidney problems when using compounded semaglutide. Additionally, sermorelin may cause joint stiffness and carpal tunnel syndrome in some patients.
Medical Monitoring Requirements
Anyone considering either medication must consult a licensed healthcare provider, who will evaluate their individual health needs and determine whether they may or may not be eligible for either or both medications.
Regular assessment should include:
Blood Sugar Monitoring: Frequent testing to maintain stable glucose levels
Cardiovascular Function: Regular monitoring due to potential fluid retention effects
Hormone Levels: Careful tracking of growth hormone and related markers
Final Thoughts
Both medications have distinct uses, each designed to address specific medical conditions or health needs. Anyone considering either medication must consult a licensed healthcare provider, who will evaluate their individual health needs and determine whether they may or may not be eligible for either or both medications.
Regular monitoring of blood glucose levels, hormone markers, and potential side effects may help ensure treatment outcomes.
FAQ
Can I take sermorelin and compounded semaglutide together?
Both medications serve different purposes—sermorelin for healthy growth hormone levels in children, and may be prescribed to adults in limited situations; and compounded semaglutide for weight loss.
Anyone considering either medication must consult a licensed healthcare provider, who will evaluate their individual health needs and determine whether they may or may not be eligible for either or both medications.
What shouldn't you mix with compounded semaglutide?
Certain foods and substances may be limited or avoided while taking compounded semaglutide to maximize effectiveness and minimize side effects. Healthcare providers may recommend combining compounded semaglutide with a proper diet and exercise while avoiding or limiting:
High-fat and greasy foods
Alcohol consumption
Sugar-sweetened beverages
Ultra-processed foods
Additionally, patients should be aware that compounded semaglutide may affect thyroid functionality and potentially interact with medications for hypothyroidism.
Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.
Ishida J, Saitoh M, Ebner N, Springer J, Anker SD, von Haehling S. Growth hormone secretagogues: history, mechanism of action, and clinical development. JCSM Rapid Communications. 2020;3(1):25-37. https://onlinelibrary.wiley.com/doi/10.1002/rco2.9
Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical interventions in aging. 2006;1(4):307-308. https://pmc.ncbi.nlm.nih.gov/articles/PMC2699646/
Ryan DH, Lingvay I, Deanfield J, et al. Long-term weight loss effects of compounded semaglutide in obesity without diabetes in the SELECT trial. Nature Medicine. 2024;30(7):2049-2057. https://www.nature.com/articles/s41591-024-02996-7
Thorner M, Rochiccioli P, Colle M, et al. Once daily subcutaneous growth hormone-releasing hormone therapy accelerates growth in growth hormone-deficient children during the first year of therapy. Geref International Study Group. The Journal of Clinical Endocrinology & Metabolism. 1996;81(3):1189-1196. https://academic.oup.com/jcem/article-abstract/81/3/1189/2649680?redirectedFrom=fulltext&login=false
17.
Holdsworth D. Traditional medicinal plants used in the treatment of gastric ailments. Papua and New Guinea medical journal. 1978;21(2):175-183. Accessed December 7, 2024. https://www.ncbi.nlm.nih.gov/books/NBK279163
Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous compounded semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity. JAMA. 2021;325(14):1414. https://jamanetwork.com/journals/jama/fullarticle/2777886
21.
Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous compounded semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity. JAMA. 2021;325(14):1414. https://jamanetwork.com/journals/jama/fullarticle/2777886
Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.