Is Semaglutide Safe? What About the Compounded Version?

In recent years, semaglutide, available under brand names like Ozempic® and Wegovy®, has gained attention as a potential medication for use in the fight against obesity. As more people turn to this prescription medication for help with weight loss, a crucial question arises: Is semaglutide safe? This concern extends not only to the FDA-approved version but also to compounded semaglutide, which has sparked debates in the medical community and among patients seeking effective weight management solutions.

‍

Key Takeaways

• General Safety: When prescribed by a healthcare provider, semaglutide is generally safe and effective for weight loss and diabetes management.
• Common Side Effects: Typical side effects include nausea, vomiting, diarrhea, and constipation, which usually decrease over time.
• Compounded Semaglutide: Compounded versions of semaglutide are tailored formulations that may have varying degrees of regulatory oversight.
• Consulting Healthcare Providers: It is crucial to consult healthcare providers before using either standard or compounded semaglutide to ensure proper dosing and monitoring.
• Long-term Safety: Both standard and compounded semaglutide require ongoing monitoring for long-term safety, with regular follow-ups to manage any adverse effects and ensure continued efficacy.

‍

What is Semaglutide?

Semaglutide is a medication in the class of drugs called GLP-1 receptor agonists. It mimics the GLP-1 hormone that your gut releases when you eat. This medication significantly impacts your body's insulin production and blood sugar control, leading to appetite suppression. You'll find semaglutide available in different forms and under various brand names:

‍

1. Ozempic®: An injectable form used to manage type 2 diabetes and reduce the risk of heart-related complications. It's important to note the differences between Wegovy® vs Ozempic® in terms of their approved uses and dosages.

2. Wegovy®: Another injectable version primarily used for weight loss in adults and some adolescents. While an Ozempic® generic is not yet available, Wegovy® offers a dedicated option for semaglutide weight loss.

3. Rybelsus: The first FDA-approved oral GLP-1 receptor agonist, providing an alternative to injections for those wondering what Ozempic® is and how it's administered.

‍

Semaglutide works by helping your pancreas release the right amount of insulin when your blood sugar levels are high. It also slows down food movement through your stomach, decreasing your appetite and leading to weight loss.

‍

Is Using Semaglutide For Weight Loss Safe?

Semaglutide has shown promising results for weight loss, but you might wonder about its safety. While the FDA has approved semaglutide for weight management under brand names such as Ozempic® and Wegovy®, it's crucial to understand its effects and potential risks, including semaglutide side effects.

‍

When you use semaglutide for weight loss, you may experience some side effects. These are typically mild and include dizziness, fatigue, headaches, and stomach issues like nausea, vomiting, and bloating. Gastrointestinal problems, such as upset stomach, are the most common complaints, especially when starting the medication. Some users also report injection site reactions with the injectable forms.

‍

To reduce these side effects, your doctor might suggest beginning with a lower dose of semaglutide and gradually increasing it. This approach can help your body adjust to the medication more comfortably. Proper dietary adjustments on semaglutide and staying hydrated can also help manage side effects.

‍

It's important to note that while semaglutide can help with weight loss, it's not suitable for everyone and has its pros and cons. You should avoid this medication if you have a history of medullary thyroid cancer, gallbladder disease, pancreatitis, or multiple endocrine neoplasia syndrome type 2 (MEN2). Your doctor will also consider your BMI criteria and medical history considerations when determining if semaglutide is appropriate for you.

‍

Before considering semaglutide for weight loss, it's essential to consult your primary care physician. They can evaluate your medical history and help determine if this treatment is appropriate, considering lifestyle factors and potential safety concerns.

‍

Common Side Effects of Semaglutide

When you start using semaglutide, you might experience some side effects. These are typically mild and often improve as your body adjusts to the medication. Here are the most common side effects you should be aware of:

‍

Nausea and Vomiting

Nausea is the most frequently reported side effect of semaglutide. Up to 20% of people taking it for type 2 diabetes have experienced nausea in clinical trials. If you're using the higher-dose version for weight loss, you're even more likely to feel nauseous. Vomiting can also occur, though it's less common than nausea. To help manage these effects:

· Eat smaller meals
· Avoid high-fat foods
· Stay upright after eating
· Give your body time to adjust to the medication

‍

Gastrointestinal Issues

You might experience various digestive problems while taking semaglutide. These can include:

· Diarrhea: About 9% of people using semaglutide for diabetes and 30% for weight loss reported this side effect.
· Constipation: Less common than diarrhea but still possible.
· Gas and bloating: These can be uncomfortable but often improve over time.
· Stomach pain: Usually mild and tends to subside as your body adapts to the medication.

‍

Other Common Side Effects

In addition to digestive issues, you might experience:

· Headache
· Dizziness
· Fatigue
· Changes in taste
· Hair loss while on semaglutide (in some cases)

‍

Remember, these side effects are usually temporary and tend to improve over time. Proper hydration and dietary adjustments can help manage symptoms.

‍

Potentially Serious Side Effects of Semaglutide

While semaglutide is generally considered safe, you should be aware of some potentially serious side effects. These are rare but require immediate medical attention if they occur.

‍

Thyroid Tumors

Semaglutide has a boxed warning from the FDA about the risk of thyroid C-cell tumors. Although this risk has only been observed in animal studies, you should be cautious. Contact your healthcare provider immediately if you notice a lump in your neck, hoarseness, trouble swallowing, or shortness of breath. These could be symptoms of thyroid cancer.

‍

Pancreatitis

Although uncommon, pancreatitis has been reported in some people taking semaglutide. If you experience severe abdominal pain that doesn't go away, with or without vomiting, seek immediate medical attention. This could be a sign of inflammation in your pancreas, which can be life-threatening if left untreated.

‍

Gallbladder Problems

Gallbladder disease, including gallstones, is another potentially serious side effect. While it affects less than 2% of people taking semaglutide, it's important to be aware of the symptoms. These include upper stomach pain, fever, and yellowing of the skin or eyes (jaundice). You might also notice clay-colored stools. If you experience any of these symptoms, inform your healthcare provider right away.

‍

Acute Kidney Injury

In rare cases, semaglutide may cause acute kidney injury, particularly in patients with pre-existing kidney issues. Symptoms can include decreased urine output, swelling in the legs or feet, and fatigue. Regular monitoring of kidney function is important for those taking semaglutide, especially if you have a history of kidney problems.

‍

Who Does Semaglutide Work Well For?

Semaglutide can be an effective option for a wide range of individuals struggling with weight management. You might be a good candidate for this medication if you're dealing with obesity or are overweight. Specifically, if you have a BMI of 30 or higher or a BMI of 27 or higher with at least one weight-related condition such as hypertension, type 2 diabetes, or high cholesterol, semaglutide could benefit you.

‍

If you've tried other weight loss methods without success, semaglutide might be a viable alternative. This includes individuals who have struggled with previous weight loss attempts and are looking for a medical-based solution. Remember, semaglutide is a prescription medication, so it's suited for those seeking a medically supervised weight loss plan.

‍

To get the most out of semaglutide, you should be committed to making lifestyle changes. While the medication can aid in weight loss, you'll achieve optimal results when you combine it with a healthy diet and regular exercise. Whether you're a busy parent trying to shed those last few stubborn pounds or someone looking to lose a significant amount of weight, semaglutide could be helpful. It's crucial to have reasonable expectations about the results and to discuss your specific situation with a healthcare provider considering patient eligibility criteria.

‍

Who Should Avoid Semaglutide?

While semaglutide can be beneficial for many, certain individuals should avoid using this medication. You should not take semaglutide if you have:

‍

· A personal or family history of medullary thyroid carcinoma (MTC)
· Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
· A known hypersensitivity to semaglutide or any of its components

‍

If you're pregnant or planning to become pregnant, you should avoid using semaglutide. It's recommended to stop using this medication at least 2 months before trying to conceive. You should also be cautious if you have a history of pancreatitis, gallbladder problems, diabetic retinopathy, or kidney issues. These conditions may worsen with semaglutide use.

‍

If you have a history of depression or suicidal thoughts, discuss this with your doctor before starting semaglutide. The medication may increase the risk of suicidal ideation in some individuals.

‍

Compounded Semaglutide: What is it?

Compounded semaglutide has gained attention due to shortages of FDA-approved versions like Ozempic® and Wegovy®. Compounding involves combining, mixing, or altering ingredients to create a medication tailored for individual patients. This process can be helpful during drug shortages, but it comes with important considerations.

‍

When you hear about compounded semaglutide, it's important to understand that it's not the same as the FDA-approved versions. There have been reports that compounding pharmacies may use different forms of the drug, such as semaglutide sodium or semaglutide acetate. These salt forms are different active ingredients than those found in approved medications, which contain the base form of semaglutide. 

‍

At Eden, we prioritize empowering our patients with the information they need to make informed decisions regarding their healthcare. One solution that has gained attention is semaglutide, an active ingredient found in the FDA-approved medications like Ozempic® and Wegovy®. Compounded oral semaglutide and semaglutide compound injection formulations may vary in their composition and effects. See our guide on semaglutide tablets vs injection for more information.

‍

Is Compounded Semaglutide Safe?

The safety of compounded semaglutide has raised concerns among health professionals and regulatory bodies. You should be aware that the FDA has not approved compounded versions of semaglutide, and their safety and effectiveness have not been proven.

‍

Compounded semaglutide may contain different forms of the drug, such as semaglutide sodium or semaglutide acetate. The FDA has stated that it needs to be made aware of any basis for using these salt forms to meet federal requirements for compounding. Only use semaglutide prescribed by a licensed healthcare provider and obtained from state-licensed pharmacies or FDA-registered outsourcing facilities to protect your health. Be cautious of products marketed as "semaglutide" that may not contain the same active ingredient as FDA-approved versions. 

‍

Final Thoughts on Semaglutide Safety

Semaglutide has emerged as a promising tool in the battle against obesity, offering hope to many struggling with weight management. Its ability to mimic the GLP-1 hormone significantly impacts appetite control and blood sugar regulation, leading to substantial weight loss for many users. It's crucial to remember that semaglutide is not a magic solution and works best when combined with a healthy lifestyle. 

‍

While compounded semaglutide has gained attention due to shortages of approved versions, it must be cautiously approached. It's essential to understand semaglutide dosages and guidelines. If you're looking for a semaglutide program, tryeden.com offers personalized plans designed to optimize weight loss and overall health. Combining expert guidance with customized dosing, Eden helps you achieve the best results with semaglutide. Remember, your weight loss journey is unique, and what works for one person may not work for another. There may also be other reasons you're not losing weight on semaglutide. Always prioritize your health and safety when considering any weight loss medication.

‍

FAQ

Does Semaglutide Mess up Your Metabolism?

Semaglutide doesn't directly affect your metabolism but can indirectly influence metabolic processes. It changes your appetite, blood sugar levels, and body composition. When you lose weight, your body might adjust its metabolic rate. This is called metabolic adaptation. Your basal metabolic rate may lower, and hormonal changes can occur. These changes can make it harder to maintain weight loss in the long run.

‍

How Much Weight Can You Lose on Semaglutide?

You can expect to lose up to 5% of your weight in the first month on semaglutide. After two months, this could increase to 8%. The real impact becomes evident after three months. Research shows that semaglutide 2.4 mg can lead to a weight loss of about 16% of your body weight, or 16-17kg, after 68 weeks. Most of this weight loss on semaglutide occurs in the first 32 weeks and then plateaus as your body adapts to the medication.

‍

Will Weight Come Back After Semaglutide?

Weight regain is common after stopping semaglutide. The more weight you lose initially, the more you might regain. Those who lose more weight initially tend to maintain a more significant weight loss than their starting weight. In one study, participants lost an average of 17.3% of their body weight after 68 weeks on semaglutide. After stopping the medication and 52 weeks of follow-up, they maintained a 5.6% weight loss.

‍

Can Semaglutide Target Belly Fat?

While semaglutide isn't specifically a belly fat burner, it can help reduce abdominal fat. It mimics the GLP-1 hormone, which sends fullness signals to your brain. This enables you to eat less and feel satisfied sooner. Semaglutide also slows digestion and increases fat oxidation, which can help break down stubborn belly fat. Results vary from person to person and depend on lifestyle, activity level, and genetics.

‍

Does Semaglutide Dehydrate You?

While dehydration isn't a direct side effect of semaglutide, some of the medication's side effects can lead to fluid loss. Nausea, vomiting, and diarrhea can all contribute to dehydration if not managed properly. It's important to stay well-hydrated while taking semaglutide, especially if you experience these side effects. Proper hydration can also help alleviate some of the digestive discomfort associated with the medication.

‍

References

‍

Moll H, Frey E, Gerber P, et al. GLP-1 receptor agonists for weight reduction in people living with obesity but without diabetes: a living benefit–harm modelling study. EClinicalMedicine. 2024;73:102661-102661. doi: https://doi.org/10.1016/j.eclinm.2024.102661

‌Wilding JPH, Batterham RL, Calanna S. Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine. 2021;384(11):989-1002. doi: https://doi.org/10.1056/NEJMoa2032183

‌Davies M, Færch L, Jeppesen OK, et al. Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial. The Lancet. 2021;397(10278):971-984. doi: https://doi.org/10.1016/s0140-6736(21)00213-0

‌Wadden TA, Bailey TS, Billings LK, et al. Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial. JAMA. 2021;325(14):1403-1413. doi: https://doi.org/10.1001/jama.2021.1831

‌Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. JAMA. 2021;325(14):1414-1425. doi: https://doi.org/10.1001/jama.2021.3224

‌Garvey WT, Batterham RL, Bhatta M, et al. Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial. Nature Medicine. 2022;28(10):2083-2091. https://www.nature.com/articles/s41591-022-02026-4

‌Kadowaki T, Isendahl J, Khalid U, et al. Semaglutide once a week in adults with overweight or obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial. The Lancet Diabetes & Endocrinology. 2022;10(3):193-206. doi: https://doi.org/10.1016/S2213-8587(22)00008-0

‌Gilson Dorneles, Algeri E, Lauterbach G, Pereira M, Fernandes B. Efficacy and safety of once-weekly subcutaneous semaglutide in adults with overweight or obesity: systematic review with meta-analysis. Experimental and clinical endocrinology & diabetes. Published online April 10, 2024. doi: https://doi.org/10.1055/a-2303-8558

‌Ruseva A, Michalak W, Zhao Z, Fabricatore A, Hartaigh BÓ, Umashanker D. Semaglutide 2.4 mg clinical outcomes in patients with obesity or overweight in a real-world setting: A 6-month retrospective study in the United States (SCOPE). Obesity Science & Practice. 2024;10(1):e737. doi: https://doi.org/10.1002/osp4.737

Wang W, Volkow ND, Berger NA, Davis PB, Kaelber DC, Xu R. Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population. Nature communications. 2024;15(1). doi: https://doi.org/10.1038/s41467-024-48780-6

‌Ryan DH, Lingvay I, Deanfield J, et al. Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial. Nature Medicine. Published online May 13, 2024:1-9. doi: https://doi.org/10.1038/s41591-024-02996-7

‌Song CE, Wang Y, Dai XM, Wu HY. Efficacy and Safety of Semaglutide in Weight Loss of Non-diabetic People. Endocrine Metabolic & Immune Disorders - Drug Targets. 2024;24. doi: https://doi.org/10.2174/0118715303283400240521120048

‍

Disclaimer: The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects, or consequences resulting from the use of any suggestions or information provided in this blog.

‌Disclaimer: The FDA does not approve compounded medicationsfor safety, quality, or manufacturing. Prescriptions and a medical evaluationare required for certain products. The information provided on this blog is forgeneral informational purposes only. It is not intended as a substitute forprofessional advice from a qualified healthcare professional and should not berelied upon as personal health advice. The information contained in this blogis not meant to diagnose, treat, cure, or prevent any disease. Readers areadvised to consult with a qualified healthcare professional for any medicalconcerns, including side effects. Use of this blog's information is at your ownrisk. The blog owner is not responsible for any adverse effects or consequencesresulting from the use of any suggestions or information provided in this blog.

‍

‍