hCG vs Semaglutide: What’s the difference?

Semaglutide and hCG have become medications of interest for people who want to lose weight and boost their health. As more people look for ways to slim down that work, the hCG vs semaglutide debate has become more prevalent. Both choices offer different methods to manage weight, but to make a smart choice, it's key to understand how they differ.

This article examines hCG and semaglutide in-depth, looking at how they work, their advantages, and their potential downsides. We'll compare hCG and semaglutide side by side, check how well they help with weight loss, and talk about possible side effects. We'll also answer common questions like whether you can use hCG and semaglutide at the same time and how they measure up to other treatments such as Ozempic^®. 

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Key Takeaways

• Semaglutide (marketed as Ozempic^®, Wegovy^®, Rybelsus^®, and SubMagna™) is a GLP-1 receptor agonist that has shown significant weight loss benefits ^[1].

• Semaglutide works by mimicking the GLP-1 hormone, reducing appetite and food intake while improving blood sugar control ^[1].

• HCG (Human Chorionic Gonadotropin) aids in fat breakdown and promotes the use of stored fats for energy.

• Combining semaglutide and HCG may lead to faster weight loss results, sustained energy levels, and reduced hunger compared to using either treatment alone.

• Pharmacologic therapy for weight loss should be considered alongside lifestyle changes, with an individualized approach based on patient factors ^[2].

• Long-term weight maintenance remains a challenge, even with medication use ^[2].

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What Is Semaglutide: An Overview

Semaglutide is a man-made substance that copies what glucagon-like peptide-1 (GLP-1) does in the body. GLP-1 is a hormone our bodies make [3]. Doctors group semaglutide with other drugs called GLP-1 receptor agonists. These drugs have been used by many for treating type 2 diabetes and have also been used in helping people lose weight [4].

Novo Nordisk created semaglutide. The U.S. Food and Drug Administration (FDA) first gave it the green light in 2017 to treat type 2 diabetes in adults [5]. Since then, companies have sold it under different brand names. Each brand has its own specific uses and forms [3].

Semaglutide has an influence on GLP-1 receptors found in the gut, pancreas, and brain [3]. This triggers several effects:

1. Better insulin release based on glucose levels

2. Slower stomach emptying

3. More pancreatic β-cell growth

4. Less glucagon release

5. Reduced hunger

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These processes help control blood sugar levels better and can lead to weight loss [3] [4].

Studies show semaglutide can lower hemoglobin A1C levels by up to 2 percentage points [4]. It may also help protect kidneys from high blood sugar damage [4].

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The FDA has approved three forms of semaglutide:

1. Ozempic^®: A shot you can take to manage type 2 diabetes

2. Wegovy®: A stronger shot designed to help with weight loss

3. Rybelsus®: A pill you can take by mouth to treat type 2 diabetes [3] [5]
4. SubMagna™: A sublingual semaglutide suspension used to help with weight loss

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If you're starting semaglutide, understanding the proper dosing and usage guidelines is essential to ensure optimal effectiveness and safety. In 2021, the FDA approved Wegovy® to manage chronic weight in obese adults or overweight people with weight-related health issues [6]. 

A prescription from a doctor is needed to get compounded semaglutide for both the injectable form and oral forms. A doctor will decide if semaglutide is right for you and which type: either the injectable form of semaglutide (Wegovy^®, Ozempic^®) or one of the oral forms of semaglutide (Rybelsus^®, SubMagna™).

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What Is hCG?

Human Chorionic Gonadotropin (hCG) is a hormone that the placenta makes during pregnancy [7]. This hormone has many uses and plays a key role in different body processes. Doctors also use it in several medical treatments.

During pregnancy, blood tests can spot hCG about 11 days after conception, while urine tests pick it up a bit later [7]. This hormone's levels shoot up fast, doubling every three days in the first eight to 10 weeks of pregnancy [7]. hCG teams up with estrogen and progesterone to make the uterine lining thicker, help the embryo grow and tell the body to stop menstruating [7].

It's worth noting that hCG comes in four different forms, each with its own job in the body and made by different cells [8]. Villous syncytiotrophoblasts make the main type, which helps produce progesterone and grow cytotrophoblast cells [8]. This teamwork supports the growth of the fetus, the development of the uterus, and the formation of the umbilical cord [8].

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Doctors use hCG for several reasons:

1. Fertility treatment: Doctors combine it with other fertility drugs to boost a woman's odds of getting pregnant [9].

2. Male hormone therapy: hCG has an impact on testosterone and sperm production in men and teenage boys [9].

3. Treatment of cryptorchidism: Doctors give hCG to male children who have this specific birth problem with their testes [9].

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Hyperglycosylated forms of hCG can help certain cancer cells grow, and free beta-subunit hCG might point to malignant cancer [8]. The anterior pituitary gland makes small amounts of hCG throughout the menstrual cycle, which copy the effects of luteinizing hormone [8].

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Pros Of Semaglutide

Pro #1: Diabetes Management

Semaglutide has shown positive results in treating type 2 diabetes. Studies prove it can cut hemoglobin A1C levels by up to 2 percentage points [4]. This significant drop helps patients reach their A1C treatment target of under 7% better than other drugs. What's more, semaglutide might shield the kidneys from high blood sugar damage, which could slow down the onset of chronic kidney disease [4].

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Pro #2: Heart Health Perks

Research shows that semaglutide may lower the chance of serious heart problems, like heart attacks and strokes, in overweight or obese adults with known heart disease. For people with diabetes, semaglutide can decrease the risk of major heart issues or death by 26% compared to a placebo [4]. Even people without diabetes can see a 20% drop in similar outcomes [4].

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Pro #3: Controlling Weight and More

Semaglutide has been shown to be effective in managing weight for people who are obese or overweight. It has an impact on more than just weight loss, offering possible benefits for different health issues. New studies hint that semaglutide might lower colorectal cancer rates in people with type 2 diabetes [10]. It also looks promising to cut down the risk of dementia in those with type 2 diabetes when compared to those given a placebo [10]. New research also points to possible benefits in lowering the risk of sudden pancreas inflammation and possibly easing symptoms of alcohol addiction [10].

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Cons of Semaglutide

Con #1: Stomach and Gut Problems

Semaglutide has an impact on the digestive system in various ways. Nausea tops the list of side effects, hitting up to 20% of type 2 diabetes patients and even more people taking the higher dosage to lose weight [11]. Vomiting doesn't happen as often, but you're more likely to experience it with larger doses [11]. Diarrhea affects about 9% of diabetes patients and 30% of those taking it to lose weight [11]. Other stomach troubles include constipation, gas, bloating, and mild stomach pain [11]. Some people might deal with acid reflux symptoms, including a unique "Ozempic^® burp" [11].

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Con #2: Other Physical and Mental Side Effects

Tiredness is a typical side effect affecting 11% of people who took Wegovy^® in clinical studies [11]. Some people say they have strange or lifelike dreams [11]. Losing weight fast can sometimes cause hair to thin or fall out [11]. There's also a chance of getting "Ozempic^® face," where some notice their face looks less full [11]. While semaglutide doesn't cause headaches, they might occur because of other side effects like not drinking enough water [11].

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Con #3: Health Dangers

Though uncommon, semaglutide can have an impact on more serious health problems. These include pancreatitis, gallbladder disease, and, in rare instances, kidney damage [11]. The FDA has issued a warning about the risk of thyroid C-cell tumors [11]. Severe allergic reactions (anaphylaxis) can occur, but they don’t happen often [11]. Some people who use it have reported severe stomach paralysis (gastroparesis) [11]. We don't yet understand the long-term effects of using semaglutide to lose weight, and we need to conduct more studies to understand what happens when people use it for long periods of time [12].

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Pros of hCG

Pro #1: Possible Weight Reduction

Human Chorionic Gonadotropin (hCG) is a possible aid for losing weight. The hCG diet consists of eating 500 to 800 calories a day while taking hCG pills or shots [14]. People who have tried this diet claim it can help you lose weight without feeling super hungry or weak [13].

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Pro #2: Fertility and Reproductive Health Advantages

hCG may have an impact on reproductive health for both men and women. In men, hCG shots can boost testosterone and sperm production, which might enhance fertility [15]. This hormone can also help to treat certain testicular problems in young boys, like testicles that haven't dropped [15]. For women, hCG is key to supporting ovulation and ensuring that eggs develop [15]. These features make hCG a useful tool to treat fertility issues and address reproductive health concerns.

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Pro #3: Possible Advantages for Male Wellness

hCG shots may bring several upsides to men's health:

1. Higher testosterone: hCG can boost the body's natural testosterone production. This has an impact on energy levels and athletic performance [15].

2. Better testicular function: hCG helps men who use anabolic steroids or testosterone replacement therapy. It can restore testicular volume and function [15].

3. Better sex drive: When men take hCG, it boosts their testosterone. This bump in testosterone can fire up their desire for sex [15].

4. Pairs well with other treatments: Guys often use hCG along with testosterone replacement. This combo can help dodge some downsides of testosterone therapy while adding extra perks [15].

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Keep in mind that while these possible benefits exist, using hCG for reasons other than its approved medical uses should be done under a doctor's supervision.

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Cons of hCG

Con #1: Possible Side Effects

hCG has an impact on users in different ways, causing side effects that range from mild to severe. People often experience bloating, stomach or pelvic pain, and nausea [16]. More dangerous effects can include less urination, bad pelvic pain, and breathing problems [16]. Sometimes, hCG makes blood clots more likely to form. Signs of this include pain, warmth, redness, numbness, or tingling in an arm or leg [17]. Some people might also get headaches, feel irritable, and notice changes in how they sleep [16].

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Con #2: Risk of Ovarian Hyperstimulation Syndrome

Women who use hCG might develop ovarian hyperstimulation syndrome (OHSS), which can be life-threatening [17]. OHSS symptoms include pelvic pain, swollen hands or legs, stomach pain and swelling, trouble breathing, weight gain, diarrhea, feeling sick or throwing up, and urinating less [17]. This risk increases after the first treatment cycle and requires immediate medical assistance if any risks occur.

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Con #3: Ineffectiveness for Weight Loss

Despite claims of weight loss, research doesn't back up hCG's effectiveness for this goal. Research comparing hCG shots to placebo treatments in low-calorie diets found the same or the same weight loss between groups [18]. Also, hCG didn't reduce hunger as claimed [18]. The hCG diet is risky, with its extreme calorie limit (about 500 calories a day) causing muscle loss and metabolic changes that make it hard to keep weight off long-term [18]. The diet may also have side effects like tiredness, crankiness, and low mood [18].

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hCG vs Semaglutide: How do they compare?

When we look at hCG and semaglutide for weight loss, we should think about how they work, how well they work, and what side effects they might cause. Semaglutide, a glucagon-like peptide-1 (GLP-1) agonist, changes how your body handles food and hunger. It makes your stomach empty slowly and makes you feel full, which helps you lose weight [19]. In the STEP 1 study, people who took semaglutide lost 15.3 kg, while those who took a placebo lost 2.6 kg over 68 weeks [20].

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Doctors can prescribe hCG (human chorionic gonadotropin) for weight loss even though it's not approved for this use. The hCG diet combines very few calories (500-800 a day) with hCG shots or pills [2]. People who back this diet say that hCG may help the body burn stored fat for energy while keeping muscle. But science doesn't back up hCG as a way to lose weight. Research shows that people lose weight on the hCG diet because they eat so little calories, not because of the hormone itself [20].

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When it comes to side effects, semaglutide can lead to stomach problems like feeling sick and having loose stools. The hCG diet's downsides stem from eating very few calories, which can make you tired, change your mood, and mess with your body's salt balance [2].

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Looking at the science and FDA approval, semaglutide seems to work and be safe for the purpose of losing weight. But everyone's body reacts differently, so it's key to talk to a doctor before you start trying to use either of these medications to lose weight.

To be sure that semaglutide is safe for you to use, consult with your doctor. Mild stomach issues are the most common side effects. But some rare and serious reactions have been seen, including:

·   Low blood sugar

·   Pain in joints and back

·   Swelling of the pancreas

·   Sudden kidney problems

·   Eye problems in people with diabetes

·   Allergic responses

·   Sudden gallbladder issues

·   Faster heart rate

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As with any medication, you should talk to a doctor to check your own risks and benefits.

Semaglutide comes in pill form, as a sublingual suspension, and as an injection. Each type has its pros and cons, and there are several factors to consider when deciding between semaglutide tablets vs injections:

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Oral forms (tablets and sublingual suspension):

·   No needles needed

·   You take them every day

·   Can make you feel sick, throw up, or have stomach pain

·   You should take them in the morning before eating and wait 30 minutes before having food

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Shots:

·   You need to use needles

·   You take them once a week

·   Might cause reactions where you inject

·   You can take them whether you've eaten or not

As with any other weight loss medication, there are pros and cons of semaglutide for weight loss.

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Pros:

·   Clinical trials show it works

·   It makes your overall health better

·   It cuts down on hunger

·   It helps control blood sugar

·   It gives you a way to manage weight without surgery

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Cons:

·   It can cause problems with your stomach and gut

·   It costs a lot even more if you don't have insurance

·   You need to take semaglutide for a long time to keep seeing results

·   You might gain weight back if you stop taking it

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To get approved for semaglutide, healthcare providers may consider prescribing semaglutide to patients who meet specific criteria, such as:

1. To lose weight (Wegovy^®): A BMI of 30 or above, or a BMI of 27 or above with at least one health problem related to weight

2. To manage diabetes (Ozempic^®, Rybelsus^®): A diagnosis of type 2 diabetes

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Always consult with your healthcare provider to determine if semaglutide is appropriate for your health needs.

Semaglutide costs can vary based on factors such as insurance coverage, pharmacy location, and individual health plans. Patients should discuss cost options with their healthcare provider and explore potential financial assistance programs offered by the manufacturer or other sources.

Semaglutide prescriptions may be accessible online through telehealth services, where patients can consult with licensed healthcare providers to determine their eligibility and possibly be prescribed semaglutide online. Eden connects patients with healthcare providers who can discuss treatment options, including semaglutide, based on individual health assessments. Eden does not manufacture or dispense medications. All prescriptions are provided by licensed healthcare providers following a consultation. 

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If people don't have insurance coverage, they might have a few options when it comes to how to get semaglutide prescriptions from a healthcare provider:

1. Novo Nordisk, which makes semaglutide products, has programs to help eligible people.

2. People may be able to get discounts at different pharmacies using services like Optum Perks.

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Without insurance, semaglutide prices can be expensive. Prices can change based on the pharmacy and where patients live. Either way, the cost of semaglutide without insurance is expected to be higher. Again, some online coupons or discount programs can help cut the cost of semaglutide treatments.

When guided by a healthcare provider, patients have successfully achieved weight loss using this medication. These semaglutide success stories show how the medication can help people manage their weight. Always talk to your doctor to figure out the best way to treat your condition.

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hCG vs Semaglutide: Final Thoughts

Treatments like hCG and semaglutide should be compared in consultation with a healthcare provider. While semaglutide is FDA-approved for specific uses, hCG is not approved for weight loss, and its effectiveness is not supported by robust scientific evidence. Always consult with a healthcare provider to determine the best and safest approach for your weight management needs. 

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Semaglutide has been shown to be effective in diabetes care and weight reduction when treatment is approved and guided by a doctor. hCG, though there are people who like to use it for weight loss, doesn't have much scientific proof behind it. It might also be risky because the diet that’s suggested to be followed while taking hCG sees people consuming very few calories per day, causing health concerns.

All statements regarding the efficacy of medications like semaglutide are based on clinical studies and should be discussed with your healthcare provider. Individual results may vary.

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When choosing between these options, make sure to think about your own health needs and talk to a doctor. When guided by a healthcare provider, semaglutide has proven to be effective, giving it a possible advantage over hCG for managing weight loss in the long run. But getting healthier isn't just about taking medicine. It's about looking at the whole picture, which includes changing your lifestyle, eating a balanced diet, exercising, and working with your healthcare provider to get results that last.

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FAQ

1. Is there a medication more effective than semaglutide for weight loss?

Recent studies have indicated that under the care of a physician, tirzepatide may be an alternative to semaglutide in aiding weight loss for individuals with obesity or who are overweight.

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2. How does semaglutide compare to Saxenda^® in terms of effectiveness?

Semaglutide (under the guidance of a healthcare provider) has been shown to be more effective than Saxenda^® (liraglutide). This effectiveness is attributed to semaglutide's longer action duration in the body, leading to better blood glucose control and weight loss management.

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3. Is hCG effective for weight loss?

There is no conclusive evidence that hCG products alone can facilitate weight loss. Weight loss observed with hCG is typically due to the extremely low-calorie diet of 500 to 800 calories per day, which can lead to temporary weight reduction.

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4. What is the potential weight loss with semaglutide over three months?

Weight loss outcomes with semaglutide can vary. Clinical studies have shown that some individuals may experience weight loss when using semaglutide as part of a comprehensive weight management plan that includes diet and exercise. Consult with your healthcare provider to understand what you might expect based on your health profile.

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References

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1. Casa de Sante. Comparing Semaglutide vs HCG for Weight Loss: Which Is More Effective? Casadesante.com. Published 2024. Accessed August 7, 2024. https://casadesante.com/blogs/gut-health/comparing-semaglutide-vs-hcg-for-weight-loss-which-is-more-effective?srsltid=AfmBOor8THsSJN4QvqcBV7KBkEVuuAMABJnYHrU_QHcKjNAYCLUrRA3b

2. Dr. V Medical Aesthetics. Semaglutide vs. hCG: The Ultimate Showdown for Lasting Weight Loss Success. Dr. V Medical Aesthetics. Published March 20, 2024. Accessed August 7, 2024. https://www.drvaesthetics.com/semaglutide-vs-hcg/

3. Kommu S, Whitfield P. Semaglutide. PubMed. Published February 11, 2024. Accessed August 7, 2024. https://www.ncbi.nlm.nih.gov/books/NBK603723/

4. Mayo Clinic. Health benefits of semaglutide — Beyond weight loss - Mayo Clinic Press. Mayo Clinic Press. Published July 2, 2024. Accessed August 7, 2024. https://mcpress.mayoclinic.org/living-well/health-benefits-of-semaglutide-beyond-weight-loss/

5. Weiman E, Suero-Salvador T. Semaglutide for Weight Loss: Benefits, Side Effects, and More. Sesame Care. Published December 19, 2023. Accessed August 7, 2024. https://sesamecare.com/blog/semaglutide-for-weight-loss

6. DrugBank. Semaglutide. Drugbank.com. Published December 6, 2017. Accessed August 7, 2024. https://go.drugbank.com/drugs/DB13928

7. Cleveland clinic. Human Chorionic Gonadotropin: Hormone, Purpose & Levels. Cleveland Clinic. Published 2022. Accessed August 7, 2024. https://my.clevelandclinic.org/health/articles/22489-human-chorionic-gonadotropin

8. Ogino MH, Tadi P. Physiology, Chorionic Gonadotropin. PubMed. Published November 7, 2022. Accessed August 7, 2024. https://www.ncbi.nlm.nih.gov/books/NBK556118/

9. Cleveland Clinic. Human Chorionic Gonadotropin, HCG injection. Cleveland Clinic. Published 2024. Accessed August 7, 2024. https://my.clevelandclinic.org/health/drugs/18559-human-chorionic-gonadotropin-hcg-injection

10. Fischer K, Blackmer N. Beyond Weight Management: 5 Other Potential Benefits of Semaglutide. Health. Published June 25, 2024. Accessed August 7, 2024. https://www.health.com/semaglutide-round-up-conditions-treatment-8657610

11. Hawkins-Jarrett Z, Aungst C. The 12 Semaglutide Side Effects You Should Know About. GoodRx. Published December 14, 2023. Accessed August 7, 2024. https://www.goodrx.com/ozempic/semaglutide-side-effects

12. Southwest Family Medical, Taylor, MD. The Pros and Cons of Semaglutide for Weight Loss - Dr. Taylor. Southwest Family Medical. Published September 7, 2023. Accessed August 7, 2024. https://swfamilymedical.com/pros-cons-semaglutide-for-weight-loss/

13. Gardner A. HCG for Weight Loss. WebMD. Published December 13, 2013. Accessed August 7, 2024. https://www.webmd.com/diet/hcg-and-weight-loss

14. Zeratsky K. HCG diet: Is it safe and effective? Mayo Clinic. Published 2018. Accessed August 7, 2024. https://www.mayoclinic.org/healthy-lifestyle/weight-loss/expert-answers/hcg-diet/faq-20058164

15. Pastore G. 6 Benefits of HCG Injections For Men - Vitality Aesthetic and Regenerative Medicine. Vitality Aesthetic and Regenerative Medicine. Published December 27, 2021. Accessed August 7, 2024. https://varmedicine.com/6-benefits-of-hcg-injections-for-men/

16. Merative, Micromedex. Chorionic Gonadotropin (Subcutaneous Route, Intramuscular Route, Injection Route) Side Effects - Mayo Clinic. MayoClinic.org. Published February 1, 2024. Accessed August 7, 2024. https://www.mayoclinic.org/drugs-supplements/chorionic-gonadotropin-subcutaneous-route-intramuscular-route-injection-route/side-effects/drg-20062846

17. Durbin K. HCG (Injection) Uses, Dosage, Side Effects. Drugs.com. Published April 19, 2024. Accessed August 7, 2024. https://www.drugs.com/hcg.html

18. Hrefna Palsdottir, MS. What Is the HCG Diet, and Does It Work? Healthline. Published October 15, 2018. Accessed August 7, 2024. https://www.healthline.com/nutrition/hcg-diet-101

19. Biorestoration Medical and Aesthetics. What is the Best Medical Weight Loss Method? Biorestoration Medical and Aesthetics. Published November 1, 2022. Accessed August 14, 2024. https://biorestoration.com/what-is-the-best-medical-weight-loss-method/

20. Sombra LRS, Anastasopoulou C. Pharmacologic Therapy For Obesity. PubMed. Published February 12, 2024. Accessed August 7, 2024. https://www.ncbi.nlm.nih.gov/books/NBK562269/

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‌Disclaimer: The FDA does notapprove compounded medicationsfor safety, quality, or manufacturing.Prescriptions and a medical evaluationare required for certain products. Theinformation provided on this blog is forgeneral informational purposes only. Itis not intended as a substitute forprofessional advice from a qualifiedhealthcare professional and should not berelied upon as personal health advice.The information contained in this blogis not meant to diagnose, treat, cure, orprevent any disease. Readers areadvised to consult with a qualified healthcareprofessional for any medicalconcerns, including side effects. Use of thisblog's information is at your ownrisk. The blog owner is not responsible forany adverse effects or consequencesresulting from the use of any suggestions orinformation provided in this blog.

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