Berberine Vs Semaglutide: Is Berberine “Nature’s Ozempic®?”

As more people seek effective ways to manage obesity, there is growing interest in both prescription medications and natural supplements. This comparison between berberine and semaglutide explores their potential roles in weight management, highlighting key differences in their mechanisms, effectiveness, and safety. It's important to note that berberine is not a substitute for Ozempic® or any other prescription medication.

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Always consult with a healthcare provider before starting any new treatment or supplement, particularly when considering alternatives to prescribed medications.

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This article explores how each of these compounds works, compares how well they manage weight, and discusses their safety. We'll also look at the price difference between berberine supplements and prescribed semaglutide and see if using these two together is okay. 

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Key Takeaways

• Berberine, an herbal supplement, has gained attention for its potential effects on metabolism and blood sugar control. However, it is not a natural alternative to semaglutide, an FDA-approved medication for weight management and diabetes ^[2].

• Dietary supplements are not regulated by the FDA in the same way as prescription drugs. Consult your healthcare provider before using supplements as part of your treatment plan.

• Studies on berberine's effectiveness for weight loss have shown modest results, with an average weight loss of about four pounds when taking 500 mg daily ^[1].

• Berberine has been used in Traditional Chinese Medicine for over 2,000 years to treat diabetes and gastrointestinal symptoms ^[2].

• Some small studies have suggested berberine may have glucose-lowering effects comparable to metformin, but larger, high-quality clinical trials are lacking ^[2].

• As a dietary supplement, berberine is not regulated by the FDA for safety and effectiveness, unlike prescription medications ^[2].

• Berberine is unsafe for pregnant and breastfeeding women, as well as children ^[3].

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What Is Semaglutide?

Semaglutide is a drug that’s known for its effectiveness in controlling type 2 diabetes and helping people lose weight. It is the main ingredient in several medicines such as Ozempic^®, Wegovy^®, Rybelsus^®, and SubMagna™[4].

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Semaglutide is part of a group of drugs called incretin mimetics GLP-1 agonists. It has an influence on the body by boosting insulin production, cutting down glucagon release, delaying stomach emptying, and reducing hunger [4] [5]. This approach, from many angles, helps to manage blood sugar and can result in significant weight reduction for some people.

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1. Ozempic^®: Helps adults with type 2 diabetes keep their blood sugar in check. It also lowers the chance of serious heart and blood vessel problems in people who already have these conditions [5].

2. Wegovy^®: Gets the green light to help adults shed pounds if they're obese or overweight with at least one health issue tied to their weight. It's also okay for obese kids 12 and up to use [5].

3. Rybelsus^®: An oral form of semaglutide used to manage blood sugar in adults with type 2 diabetes [4].

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You need a medical consultation and prescription from a doctor to get compounded semaglutide for both the injectable form and oral forms. Your doctor will decide if semaglutide is right for you and which type: either the injectable form of semaglutide (Wegovy^®, Ozempic^®) or one of the oral forms of semaglutide (Rybelsus^®, SubMagna™). Semaglutide doesn't work for people with type 1 diabetes, and you can't get it as a generic drug [4].

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How Does Semaglutide Work?

Semaglutide acts as a glucagon-like peptide-1 (GLP-1) receptor agonist. It has a structure that's 94% similar to human GLP-1 [6]. To have an effect, it targets GLP-1 receptors. These receptors are found in the gut, pancreas, and brain [6].

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When semaglutide turns on the GLP-1 receptor, it boosts insulin release based on glucose levels. This provides a natural response to high blood sugar after eating [6]. This action helps to reduce blood glucose levels, both when fasting and after meals [7]. Research has shown that compounded semaglutide can trigger a similar insulin response in people with type 2 diabetes as in those without the condition [7].

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Semaglutide influences other body functions that help make it work well:

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1. It lowers glucagon release in a way that depends on glucose levels [7].

2. It slows down stomach emptying, which means glucose enters the bloodstream more after eating [7].

3. It interacts with GLP-1 receptors in the hypothalamus, which may reduce hunger, ease food cravings, and boost feelings of fullness [6].

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Semaglutide is a "long-acting" GLP-1 receptor agonist, with its elimination half-life lasting about seven days [6] [7]. Two structural changes give it this extended half-life: one that encourages albumin binding, which leads to slower renal clearance, and another that protects it from breaking down due to the dipeptidyl peptidase-4 (DPP-4) enzyme [6].

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These actions work together to help semaglutide control blood sugar levels and promote weight loss in people who are obese or overweight [8]. By mimicking a natural hormone that controls hunger and blood sugar, semaglutide tablets work by helping people manage their weight by reducing food cravings. Semaglutide typically begins to suppress appetite within a few days to a week of starting the medication, with more noticeable effects developing over the first few weeks.

Semaglutide comes in pill form, as a sublingual suspension, and as an injection. Each type has its pros and cons, and there are several factors to consider when deciding between semaglutide tablets vs injections. Following semaglutide safety guidelines will help you cut down on possible side effects and get the best results as you work to manage your weight.

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What is Berberine?

Berberine, a yellow and bitter compound, can be found in plants like European barberry, goldenseal, goldthread, Oregon grape, phellodendron, and tree turmeric [9]. This bioactive substance belongs to the alkaloid family of chemicals [10]. People have used berberine in traditional Chinese medicine for hundreds of years to treat different health problems [10].

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Over the last few years, new scientific studies have started to reveal how berberine might boost health. Research points to its potential to help with several issues related to metabolism, such as:

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1. Diabetes: Berberine could play a role in keeping blood sugar levels in check [11] [10].

2. High cholesterol: It may have an impact on managing cholesterol and other fats in the blood [9].

3. High blood pressure: Research suggests berberine might help to reduce blood pressure [9].

4. Obesity: Studies show berberine could aid in losing weight [10].

5. Heart health: Berberine may boost heart function, helping people with certain cardiac issues [9].
6. Gut health: Berberine might help improve gut health and could contribute to treating conditions like depression and nonalcoholic fatty liver disease (NAFLD) [10].

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If you're considering semaglutide alternatives, options like liraglutide or other GLP-1 receptor agonists might be effective for weight management and blood sugar control. It's important to discuss these alternatives with your healthcare provider to determine the best fit for your needs and health goals.

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Although berberine seems safe with minimal side effects, you should talk to your doctor before adding it to your routine. This is true if you take other medicines or have health issues [11]. This caution matters because berberine is a dietary supplement, which means the FDA doesn't check its safety or how well it works [10]. 

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While there isn’t a "natural semaglutide" available, some people seek natural alternatives that support weight management and blood sugar control, such as dietary changes and increased physical activity. It’s essential to consult with your doctor before pursuing these options to make sure they complement your overall treatment plan.

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How Does Berberine Work?

Berberine, a bioactive compound found in several plants, takes a multi-pronged approach to boosting metabolic health. It enters the bloodstream and goes to cells, where it interacts with different molecular targets [12]. This versatile compound influences many processes in the body, making it useful for tackling several health issues at once.

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One of the main ways berberine works is by turning on AMP-activated protein kinase (AMPK), an enzyme that controls metabolism and energy levels in the body [10]. When AMPK gets activated, berberine influences different metabolic processes, such as how glucose enters cells, how well insulin works, and how fats are broken down [13].

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Berberine has a notable impact on glucose metabolism. It speeds up glycolysis, boosts insulin release, and stops gluconeogenesis and fat cell formation in the liver [13]. Berberine makes cells more responsive to insulin and moves more glucose transporter 4 (GLUT4) to the cell surface, which helps cells take in glucose [14].

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Berberine has also been found to boost the levels of glucagon-like peptide-1 (GLP-1), an incretin hormone that plays a key part in keeping pancreatic cells alive and helping them release insulin [14]. This rise in GLP-1 helps to improve insulin secretion when glucose levels are high.

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Berberine also influences lipid metabolism. It stops adipocyte differentiation by lowering the expression of important transcription factors involved in adipogenesis, like PPARγ and SREBP-1c [14]. This action helps to hold back fatty acid biosynthesis, which is often linked to insulin resistance.

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What's more, berberine has an effect on anti-inflammatory and antioxidant activities. It has an impact on the transcription factor NF-κB, which leads to the expression of pro-inflammatory cytokines [14]. This anti-inflammatory effect might boost berberine's overall metabolic benefits.

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Berberine vs Semaglutide: A Comparison

Berberine: Weight Loss Effectiveness

While some studies suggest berberine may support weight management by improving insulin sensitivity and glucose metabolism, it does not produce the same level of weight loss as semaglutide. 

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The effectiveness of berberine for weight loss has not been established through large-scale clinical trials, and it should not be used as a replacement for prescribed medications without consulting a healthcare provider.

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Research from 2023 found that obese people who took 1.5 grams of berberine for 24 weeks saw their body mass index (BMI) and waist size go down [3]. Berberine might make insulin work better by helping the body use glucose. This can make people feel less hungry and have fewer cravings [15].

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Semaglutide: Weight Loss Effectiveness

Semaglutide, an FDA-approved medication, has demonstrated significant weight loss outcomes in clinical studies. Its effects on weight management are well-documented, and it is prescribed for individuals with specific health conditions, such as obesity and type 2 diabetes. Berberine should not be viewed as a direct substitute for semaglutide or any other prescription medication. Always discuss treatment options with your healthcare provider.

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A 68-week study revealed that patients who took a 2.4mg dose of semaglutide along with lifestyle changes lost about 34 pounds on average. In contrast, those who didn't take the medication lost around 6 pounds [15]. Semaglutide affects weight loss by slowing down how food moves through the stomach. This leads to decreased appetite and helps people shed pounds [3].

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Berberine: Safety

While berberine is generally considered safe for many people, it can cause gastrointestinal side effects such as nausea or vomiting. Additionally, berberine may interact with certain medications, so it is important to consult a healthcare provider before adding it to your routine. 

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As a dietary supplement, berberine is not subject to the same FDA regulations as prescription medications. Its safety and efficacy for specific health conditions, including weight management, are not as well-established.

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Pregnant women, nursing mothers, and children should not take it [3]. Berberine might not mix well with some medicines. These include drugs to lower blood pressure, stop blood clots, or reduce blood sugar [3]. Always check with your healthcare provider for safety protocols and guidance.

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Semaglutide: Safety

Semaglutide has been used to help people lose weight. These include adults with obesity or those who are overweight and have at least one health problem linked to their weight [4]. Doctors don't suggest it for people who have type 1 diabetes [4].

Knowing how long semaglutide stays in your system is important. It sticks around for several weeks because it has a long half-life of about one week. This means that even after you stop taking the medication, it continues to have an effect as your body gets rid of it. Sticking to semaglutide safety guidelines will help you cut down on possible side effects and get the best results as you work to manage your weight.

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Berberine: Cost

Berberine costs less than semaglutide. You can buy a 90-count bottle of berberine supplement for about $40 [17].

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Semaglutide: Cost

The semaglutide costs can add up quickly if your insurance doesn't cover it. Prices can change based on your insurance plan, where you buy the semaglutide, and other factors. Research shows patients might pay up to 68% of the cost themselves for weight loss drugs.

Semaglutide, which companies sell under names like Ozempic^®, can set you back $1,000 or more each month [17]. This big price gap makes berberine easier to afford for many people looking to manage their weight.

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Semaglutide vs Berberine Pros And Cons

Semaglutide Pros

• Weight reduction: Studies show participants shed about 15% of their body weight [18].
• Hunger management: Semaglutide copies GLP-1, which helps to control appetite [18].
• Blood sugar control: This has a positive effect on people with type 2 diabetes [18].

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Semaglutide Cons

• Side effects: Nausea, diarrhea, constipation, and stomach pain are common problems [18].
• Administration: You need to inject it once a week, which some people might find bothersome [18].
• Cost: It can hit your wallet hard, with prices from $935 to over $1,000 each month [19].
• Long-term effects: Researchers don't know much about them yet, as they need to study extended use more [18].

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Berberine Pros

• Health benefits for metabolism: Has an influence on diabetes treatment high cholesterol, and high blood pressure [11].
• Cheaper option: Costs less than most prescription drugs [9].
• Plant-based choice: Comes from plants and attracts people who want natural solutions [9].

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Berberine Cons

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• Weight loss isn't dramatic: The results don't match up to semaglutide [11].
• Watch out for drug interactions: It can mix with meds like metformin and change blood sugar [11].
• Expect some stomach troubles: You might get diarrhea, constipation, gas, or an upset stomach [9].
• Regulation: The FDA doesn't keep tabs on berberine's safety and effectiveness since it's a dietary supplement [9].

Each approach has its pros and cons. Talk to a doctor to figure out which option works best for you, considering your health and situation.

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Berberine vs Semaglutide Overall

Berberine and semaglutide have both been utilized for weight control, but they differ in how well they work, how safe they are, and how they're regulated. Semaglutide, which you find in drugs like Ozempic^® and Wegovy^®, has shown positive weight loss results. Berberine has had a less impressive impact. The big difference in how well they work comes from how they act in the body. Semaglutide acts like the hormone GLP-1, which controls hunger and helps make insulin, while berberine works in other ways, like turning on AMPK [20].

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Why Choose Semaglutide Over Berberine For Weight Loss

1. Proven Effectiveness: Large studies have shown that semaglutide can help people lose a lot of weight [15].

2. FDA Approval: The FDA says it's okay for some groups of people to use semaglutide to lose weight, but they haven't said the same about berberine [2].

3. Mechanism of Action: Semaglutide copies GLP-1, which makes it work better to control appetite and help people lose weight [1].

4. Quality Control: Semaglutide, as a prescribed drug, goes through tough quality checks. This doesn't happen with dietary add-ons like berberine [2].

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Many people have been successful in losing weight using semaglutide. These semaglutide success stories show how semaglutide can help people lose weight and boost their overall health when paired with a healthy diet and exercise. Always talk to your doctor to figure out the best way to treat your condition, as it's important to understand semaglutide dosages and guidelines. Follow your healthcare provider's instructions carefully and report any side effects or concerns you may experience while using semaglutide.

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Final Thoughts On Berberine and Semaglutide

Comparing berberine and semaglutide gives us insight into two different ways to manage weight. Semaglutide has a big impact on weight loss, as shown by clinical trials. It also improves metabolic health. Berberine, on the other hand, offers a more modest option that might be easier to get. People choose between these options based on their health needs, how much money they can spend, and what they prefer.

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While both berberine and semaglutide have been explored for their roles in weight management, they differ significantly in their effectiveness, regulatory oversight, and safety profiles. Semaglutide is a clinically validated treatment for obesity and type 2 diabetes, while berberine is a supplement with more modest effects and less regulatory oversight.

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Consult with a healthcare provider to determine the most appropriate treatment for your health needs. Do not substitute prescribed medications with dietary supplements without professional advice.

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Semaglutide works well and has FDA approval, making it a strong choice for people dealing with obesity when they also change their lifestyle. Berberine, being natural and cheaper, might appeal to people who want a milder approach or can't get prescription drugs. Remember, it's essential to talk to a doctor to figure out the best option based on your own situation and health goals.

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See more:

• Contrave vs Semaglutide
• hCG vs Semaglutide
• Metformin vs Semaglutide
• Phentermine vs Semaglutide

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FAQ

Does Berberine Work Like Ozempic^®?

Berberine and Ozempic^® (semaglutide) influence blood sugar and weight, but they work in different ways. Berberine turns on the enzyme AMP-activated protein kinase (AMPK), which controls metabolism and affects blood sugar levels [3]. Ozempic^®, however, copies the hormone GLP-1, which slows down how food moves through the stomach and reduces hunger [3].

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Why Don't Doctors Recommend Berberine?

Doctors might be cautious about suggesting berberine for a couple of reasons:

1. No FDA oversight: Berberine falls under the dietary supplement category, which means it doesn't face the same strict rules as prescription meds.

2. Not enough studies: We don't have many large, thorough trials looking into how well berberine works and how safe it is.

3. Potential side effects: Berberine has an impact on digestion, causing diarrhea [1].

4. Drug interactions: Berberine might interact with medications that lower blood pressure, stop blood clots, or decrease blood sugar [3].
   
   

Can You Take Semaglutide And Berberine Together?

Some clinical trials show that berberine can help lower blood sugar levels and boost heart health markers, similar to metformin's effects. You should talk to your doctor before you mix berberine with semaglutide or any other drug [1]. Berberine might interact negatively with other drugs and supplements, which could lead to a strong effect when taken with blood sugar-lowering meds [3].

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References

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1. Weiss H. Why the Supplement Berberine Is Not “Nature’s Ozempic.” TIME. Published June 8, 2023. Accessed August 11, 2024. https://time.com/6285790/berberine-natures-ozempic-does-it-work/

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2. Middelton J. Weight Loss Fad Berberine (“Nature’s Ozempic”) Lacks Rigorous Evidence, Has Potential Harms. American Family Physician. Published July 3, 2023. Accessed August 11, 2024. https://www.aafp.org/pubs/afp/afp-community-blog/entry/weight-loss-fad-berberine-natures-ozempic-lacks-rigorous-evidence-has-potential-harms.html

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3. Reed K, Blackmer N. Berberine Dubbed “Nature’s Ozempic” on Social Media—But Is the Supplement Safe?. Health. Published May 26, 2024. Accessed August 11, 2024. https://www.health.com/berberine-natures-ozempic-safety-7506050

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4. Puckey M. Semaglutide: uses, dosage, side effects, brands. Drugs.com. Published March 13, 2024. Accessed August 11, 2024. https://www.drugs.com/semaglutide.html

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5. MedlinePlus. Semaglutide injection: MedlinePlus drug information. medlineplus.gov. Published August 15, 2022. Accessed August 11, 2024. https://medlineplus.gov/druginfo/meds/a618008.html

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6. Kommu S, Whitfield P. Semaglutide. PubMed. Published February 11, 2024. Accessed August 11, 2024. https://www.ncbi.nlm.nih.gov/books/NBK603723/

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7. novoMEDLINK. Ozempic® (semaglutide) injection 0.5 mg or 1 mg Mechanism of Action. novoMEDLINK.com. Published January 23, 2023. Accessed August 11, 2024. https://www.novomedlink.com/diabetes/products/treatments/ozempic/about/mechanism-of-action.html

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8. UCLA Health. Semaglutide, also known as Ozempic, for weight loss - what you need to know. UCLAhealth.org. Published January 12, 2023. Accessed August 11, 2024. https://www.uclahealth.org/news/article/semaglutide-weight-loss-what-you-need-know

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9. WebMD. Berberine: Uses, Side Effects, Interactions, Dosage, and Warning. Webmd.com. Published 2019. Accessed August 11, 2024. https://www.webmd.com/vitamins/ai/ingredientmono-1126/berberine

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10. Gunnars K, Biggers A. Berberine: A Powerful Supplement With Many Benefits. Healthline. Published January 14, 2017. Accessed August 11, 2024. https://www.healthline.com/nutrition/berberine-powerful-supplement

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11. Berry J, Biggers A. Berberine: Benefits, how to use, side effects, and warnings. Medical News Today. Published October 20, 2023. Accessed August 11, 2024. https://www.medicalnewstoday.com/articles/325798

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12. Cleveland Clinic. What To Know About Berberine: Benefits, Uses and Side Effects. Cleveland Clinic. Published June 19, 2023. Accessed August 11, 2024. https://health.clevelandclinic.org/berberine-for-insulin-resistance-weight-loss

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13. Och A, Och M, Nowak R, Podgórska D, Podgórski R. Berberine, a Herbal Metabolite in the Metabolic Syndrome: The Risk Factors, Course, and Consequences of the Disease. Molecules (Basel, Switzerland). 2022;27(4):1351. doi: https://doi.org/10.3390/molecules27041351

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14. Utami AR, Maksum IP, Deawati Y. Berberine and Its Study as an Antidiabetic Compound. Biology. 2023;12(7):973. doi: https://doi.org/10.3390/biology12070973

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15. Cody Stanford, MD F. Is Berberine Nature’s Semaglutide? Cardiometabolic Health Congress. Published June 8, 2023. Accessed August 11, 2024. https://www.cardiometabolichealth.org/article/is-berberine-natures-semaglutide/

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16. Lovelace, Jr B. What is berberine, the supplement dubbed “nature’s Ozempic” on social media?. NBC News. Published June 1, 2023. Accessed August 11, 2024. https://www.nbcnews.com/health/health-news/berberine-supplements-what-to-know-benefits-risks-side-effects-rcna87065

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17. Onque R. TikTokers say berberine is “nature’s Ozempic”: Here’s what doctors want you to know about the buzzy supplement. CNBC. Published June 28, 2023. Accessed August 11, 2024. https://www.cnbc.com/2023/06/28/berberine-is-being-called-natures-ozempic-heres-what-to-know.html

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18. Southwest Family Medical, Taylor, MD. The Pros and Cons of Semaglutide for Weight Loss - Dr. Taylor. Southwest Family Medical. Published September 7, 2023. Accessed August 11, 2024. https://swfamilymedical.com/pros-cons-semaglutide-for-weight-loss/

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19. Garone S, Gilden A. Semaglutide Weight Loss Drugs: Pros, Cons, and Considerations. EverydayHealth.com. Published June 30, 2023. Accessed August 11, 2024. https://www.everydayhealth.com/weight/here-is-when-doctors-say-to-consider-a-weight-loss-drug-like-ozempic/

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20. Stokes V. “Nature’s Ozempic”: Can Berberine Really Help You Lose Weight?. Healthline. Published June 13, 2023. Accessed August 11, 2024. https://www.healthline.com/health-news/natures-ozempic-can-berberine-really-help-you-lose-weight

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‌Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog.

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