AOD 9604 Vs. Semaglutide: Differences, Pros & Cons

AOD 9604 and semaglutide compounds offer different ways to tackle weight loss problems, making health-focused people curious about which drug is more effective. As people keep looking for the best ways to manage weight, it's key to understand the differences between AOD 9604 and semaglutide.

This article explains the differences between AOD 9604 and semaglutide, covering how they work, their benefits, and their downsides. By looking at these two compounds, you'll learn about their weight loss effects, usage, and side effects. If you're considering AOD 9604 or semaglutide treatment, this guide will help you understand your weight management options. 

‍

Key Takeaways

• AOD 9604 is a peptide that has been studied for its potential effects on fat metabolism. It is not FDA-approved for weight loss or any other medical use. Understanding the differences between AOD 9604 and semaglutide, a GLP-1 receptor agonist approved for certain uses, can help individuals make informed decisions about their weight management options. Always consult a healthcare provider before starting any new treatment, especially those that are not FDA-approved.

• Semaglutide, an FDA-approved GLP-1 receptor agonist, works by mimicking the natural GLP-1 hormone, which helps regulate appetite, blood sugar levels, and digestion. It has been shown to be effective in clinical trials for managing type 2 diabetes and supporting weight loss in specific populations. Semaglutide should be used under the supervision of a healthcare provider and as part of a comprehensive treatment plan.

• AOD 9604 is a peptide that has been researched for its potential to influence fat metabolism, though it is not FDA-approved for any medical use, including weight loss. While some studies suggest it may have effects on fat cells, more research is needed to fully understand its safety and effectiveness. AOD 9604 is considered experimental and should only be used under the guidance of a healthcare provider.

• Both compounds have shown promise in weight management, but their mechanisms differ. Semaglutide influences appetite regulation in the brain, while AOD 9604 enhances lipolysis and fat utilization.

• Results may vary for individuals using either compound. For AOD 9604, significant results may take up to 12 weeks, and success is often greatest when combined with a healthy diet and exercise regimen ^[2].

• Semaglutide has undergone clinical trials, while AOD 9604 requires further research to definitively establish its effectiveness ^[3].

‍

What Is Semaglutide?

Semaglutide is a peptide and part of a group of medicines called glucagon-like peptide-1 (GLP-1) receptor agonists, which was first made to treat type 2 diabetes [4]. But its significant effect on helping people shed pounds has turned it into a real game-changer for treating obesity, too [5].

This drug works to copy what GLP-1 does. GLP-1 is a hormone our bodies make. It plays a part in controlling insulin release, how we process sugar, and how hungry we feel [5]. Semaglutide turns on GLP-1 receptors. These receptors are found in the gut, pancreas, and brain. This has an impact on many systems in the body [4].

Semaglutide works by making people feel full and less hungry. It targets the brain's hunger control areas, helping people eat less [5]. Also, semaglutide slows down how fast the stomach empties. This makes the feeling of fullness last longer after meals and helps stop cravings [5] [6].

You need a medical consultation and prescription from a doctor to get compounded semaglutide for both the injectable form and oral forms. Your doctor will decide if semaglutide is right for you and which type: either the injectable form of semaglutide (Wegovy^®, Ozempic^®) or one of the oral forms of semaglutide (Rybelsus^®, SubMagna™). The FDA has approved each of these for particular uses [4]. 

‍

How Does Semaglutide Work?

Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, works by copying what GLP-1 does. GLP-1 is a hormone our bodies make [4]. This drug looks a lot like human GLP-1 - they're 94% alike in structure. This lets it turn on GLP-1 receptors in the gut, pancreas, and brain [4].

Semaglutide's main action is to boost insulin release based on glucose levels, which helps control blood sugar after eating [4]. It also helps pancreatic β-cells grow and reduces glucagon production, leading to less hunger [4] [5]. Semaglutide typically begins to suppress appetite within a few days to a week of starting the medication, with more noticeable effects developing over the first few weeks.

Semaglutide's interaction with GLP-1 receptors in the hypothalamus has a big impact on weight management. It reduces hunger, lessens food cravings, and makes people feel fuller [4]. This effect on the brain's reward centers makes high-calorie tasty foods less appealing, which helps people stick to their diet plans [5].

Another critical part of semaglutide is its ability to boost basal metabolic rate, which helps burn more calories even when resting [5]. On top of that, it helps break down stored fat through improved lipolysis, which also aids in weight loss [5].

Semaglutide's long-acting nature contributes to its effectiveness. Its structure allows it to bind to plasma albumin, which leads to slower kidney clearance and guards against breakdown by the dipeptidyl peptidase-4 (DPP-4) enzyme [4]. This key feature gives semaglutide a longer half-life and lasting effects. Sticking to semaglutide safety guidelines will help you cut down on possible side effects and get the best results as you work to manage your weight with this treatment.

Semaglutide comes in pill form, as a sublingual suspension, and as an injection. Each type has its pros and cons, and there are several factors to consider when deciding between semaglutide tablets vs injections. By mimicking a natural hormone that controls hunger and blood sugar, semaglutide tablets work by helping people manage their weight by reducing food cravings.

Compounded semaglutide can be used when tailored dosing or specific formulations are needed that aren’t available in standard prescriptions, offering more flexibility for individual patient needs. It’s important to consult with a healthcare provider to ensure the compounded version is safe, effective, and sourced from a reputable source like Eden. 

‍

If you're looking for a reputable semaglutide program, tryeden.com offers personalized plans designed to optimize weight loss and overall health. Combining expert guidance with customized dosing, Eden helps you achieve the best results with semaglutide.

‍

What Is AOD 9604?

AOD 9604, which stands for Anti-Obesity Drug, is a peptide piece from the C-terminal part of human growth hormone (hGH) [9]. AOD 9604 contains a specific chain of amino acids that matches the 177-191 part of hGH made to use the fat-burning traits of growth hormone without affecting other body parts [10]. The comparative effectiveness of semaglutide and AOD 9604 should be evaluated by a healthcare provider based on individual patient needs and the current state of clinical evidence.

AOD 9604, first created to treat obesity, shows promise to break down fat and stop fat production [11]. It copies how natural growth hormones control fat metabolism but don't cause the bad effects on blood sugar or tissue growth that often come with unmodified growth hormones [12].

One of the main benefits of AOD 9604 is how it targets fat tissue. Unlike full-length hGH, which can affect many organs and tissues in the body, AOD 9604 has an influence on fat cells [10]. This focus allows it to make fat cells release stored triglycerides, helping to lose fat without changing other body functions [11].

Studies show that AOD 9604 might have more uses than just cutting fat. Right now, researchers are looking into how it could help with joint pain, high cholesterol, and bone and cartilage health [11]. What's key is that AOD 9604 has proven to be safe. In fact, it has been "Recognized as Safe" (GRAS) for humans in the U.S. [11].

If you're considering semaglutide alternatives, options like AOD 9604 might be effective for weight management. It's important to discuss these alternatives with your healthcare provider to determine the best fit for your needs and health goals.

‍

How Does AOD 9604 Work?

AOD 9604 is a peptide fragment that comes from the C-terminal end of human growth hormone (HGH). Scientists created it to help people lose fat without the negative effects that come with using full HGH[1]. 

It helps break down fat and stops new fat cells from forming. Unlike HGH, AOD 9604 doesn't change growth or insulin resistance. Instead, it focuses on getting rid of fat[1]. People often use it to lose weight to reduce belly fat. But, researchers are still studying how well it works and if it's safe to use. So, it's a good idea to talk to a doctor before you think about trying it[2].

‍

Semaglutide and AOD 9604 Compared

AOD 9604: Weight Loss Effectiveness

AOD 9604, a peptide piece from human growth hormone, might help burn fat without building muscle. It makes the body break down fat and stops it from making more [1]. But we don't know much about how well AOD 9604 works. In a study that lasted 24 weeks with 536 people, the drug didn't help them lose much weight. Because of this, they stopped working on it in 2007 [1].

‍

Semaglutide: Weight Loss Effectiveness

Semaglutide has demonstrated significant weight loss effects in clinical trials, making it a well-supported option for managing weight in individuals with specific medical needs. In contrast, AOD 9604, while of interest for its potential fat metabolism effects, lacks the robust clinical evidence needed to support its use as a weight loss treatment. 

‍

An effective semaglutide tip for weight loss is to combine the medication with a balanced diet and regular exercise to maximize results. Additionally, staying consistent with your doses and monitoring your progress can help you achieve and maintain your weight loss goals.

‍

AOD 9604: Safety

The safety and tolerability of AOD 9604 are still being studied. While some research suggests it may be well-tolerated, its long-term safety profile has not been fully established. It is important to discuss any potential treatment with a healthcare provider, especially if the treatment is not FDA-approved. Any use of AOD 9604 should be closely monitored by a healthcare professional.

Studies didn't report any serious side effects linked to taking AOD 9604, and researchers didn't find anti-AOD 9604 antibodies in patients [16]. Unlike full-length human growth hormone, AOD 9604 doesn't affect blood sugar levels or serum IGF-1 levels [16].

‍

Semaglutide: Safety

Common problems include stomach issues like sickness, throwing up, loose stools, or constipation [1]. There's also a chance it could cause thyroid C-cell tumors, so doctors need to keep an eye on this [1]. 

If you’re wondering how long semaglutide stays in your system, it has a half-life of about a week. This means it can linger in your system for several weeks after you take your final dose. Sticking to semaglutide safety guidelines will help you cut down on possible side effects and get the best results as you work to manage your weight.

‍

AOD 9604: Cost

The cost of AOD 9604 is going to widely depend on where you’re purchasing the drug from. Patients can purchase AOD 9604 500 mcg acetate ODT 30 melts, one daily, for approximately $300 [22]. Patients can purchase a vial of AOD 9604 5 mg compound from a different prescriber for approximately $52 [23]. As you can see, the spectrum of cost varies greatly. Consult your prescriber for current, individual pricing.

‍

Semaglutide: Cost

The semaglutide costs can add up quickly if your insurance doesn't cover it. Prices can change based on your insurance plan, where you buy the semaglutide, and other factors. Research shows patients might pay up to 68% of the cost themselves for weight loss drugs. The medication has a high price tag, with list prices ranging from $935 to over $1,000 for each injection pen [18].

‍

‍

Semaglutide vs AOD 9604: Pros And Cons

Semaglutide Pros

1. Weight Reduction: Studies in clinical settings show that semaglutide has an impact on weight, causing a drop of about 15% in body weight [17].

2. Hunger Management: Semaglutide copies what GLP-1 does, which helps to control appetite and cut down on hunger [17].

3. Blood Sugar Regulation: This medication affects blood sugar levels, making it useful for people with type 2 diabetes [17].

4. Non-Invasive Option: Semaglutide offers a way to lose weight without resorting to invasive procedures like bariatric surgery [17].

‍

List Semaglutide Cons

1. Side Effects: Nausea, diarrhea, constipation, and stomach pain are common side effects [17].

2. Administration Method: Semaglutide requires weekly shots if using the injectable method, which some people might find bothersome [17].

3. Cost: The medication has a high price tag, with list prices ranging from $935.77 to over $1,000 for each injection pen [18].

4. Long-Term Effects Unknown: Semaglutide is a new drug, so doctors don't yet understand its long-term effects when used to lose weight [17].

‍

AOD 9604 Pros

1. Fat-Burning Properties: AOD 9604 influences fat loss and blocks fat production, zeroing in on fat stores in areas with high concentrations [19].

2. Metabolic Boost: The peptide ramps up the pituitary gland, which might speed up metabolism [19].

3. Joint and Muscle Benefits: AOD 9604 has the potential to ease discomfort in joints, cartilage, and muscles [19].

4. Minimal Side Effects: AOD 9604 carries a lower risk of side effects when compared to other weight loss supplements [20].

‍

AOD 9604 Cons

1. Lack of Enough Clinical Proof: Some studies back its use, but we need more research to prove AOD 9604 helps humans lose weight [19].

2. Need for Lifestyle Shifts: AOD 9604 works best when you also exercise often and eat healthy food [19].

3. Misuse Risk: People worry about AOD 9604's wrong use in non-obese individuals [18].

4. Supply Problems: Loose prescribing habits might limit access for those who need it most [18].

‍

AOD 9604 vs Semaglutide Overall

AOD 9604 and semaglutide are two different compounds people use to manage their weight. Each works in its own way. AOD 9604 is a lab-made peptide that comes from human growth hormone. It helps break down fat cells and makes the body use stored fat better [2]. Early studies show it might work well. Some people who tried it lost a lot of weight [2]. But we need more studies to know for sure how well it works.

‍

Semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), has shown impressive results in helping people manage their weight. It works by copying what natural GLP-1 does, which cuts down hunger, makes you feel fuller, and slows down how fast you digest food [11]. Studies have proven that it helps obese people lose a significant amount of weight. An extensive study found that people taking semaglutide lost about 15.3% of their weight, while those taking a placebo lost 2.4% [2].

‍

Why semaglutide has an advantage over AOD 9604 for weight loss

Semaglutide has a more significant impact than AOD 9604 in several ways when it comes to losing weight:

1. Strong Proof from Studies: Doctors have tested semaglutide a lot, and it always helps people lose a good amount of weight [2].

2. Multifaceted Approach: This approach has an influence on weight loss and improves blood sugar control. People with type 2 diabetes find it helpful [11].

3. FDA Approval: The FDA has approved semaglutide to manage weight. This approval gives people confidence in its safety and how well it works [2].

4. Comprehensive Metabolic Effects: Semaglutide has a positive impact on insulin secretion and blood sugar disposal, in addition to weight loss [11].

‍

AOD 9604 shows promise, but its clinical evidence is not as extensive as the proven benefits of semaglutide for weight loss. Several semaglutide success stories show how this drug can help people lose weight and boost their overall health when paired with a healthy diet and exercise. If you're starting semaglutide, understanding the proper dosing and usage guidelines is essential to ensure optimal effectiveness and safety. Always consult with your healthcare provider.

‍

Final Thoughts On AOD 9604 And Semaglutide

AOD 9604 and semaglutide are two compounds studied for their effects on weight management, though they differ significantly in terms of clinical evidence and FDA approval. Semaglutide has undergone testing and is approved for specific uses in managing weight and blood sugar. AOD 9604 remains an experimental treatment with limited evidence supporting its effectiveness. It's crucial to consult with a healthcare provider to determine the most appropriate and safe treatment options. Always consult a healthcare provider before considering new or experimental treatments for weight management.

‍

Clinical trials have demonstrated that semaglutide impacts weight reduction and boosts metabolic health. Its capacity to curb hunger and slow digestion has caused a revolution in obesity treatment. AOD 9604 shows promise, but researchers need to conduct more studies to confirm how well it works.

‍

When picking between these choices, you need to think about your own health needs, possible side effects, and what your doctor says. Both of these drugs could have an impact on how we manage weight, but we're still figuring out their long-term effects and the best ways to use them. 

‍

FAQ

Can You Take Semaglutide And AOD 9604 Together?

The combination of AOD 9604 and semaglutide for weight loss has not been thoroughly studied and should be approached with caution. While some experimental studies suggest potential benefits, the safety and efficacy of using these treatments together have not been established. Consultation with a healthcare provider is essential before considering such a combination. 

‍

The combination of treatments should only be considered under medical supervision, with full awareness of the potential risks and benefits.

‍

This mix might have a stronger effect than regular weight loss methods [21]. AOD 9604 helps release fatty acids from fat tissue, while semaglutide reduces appetite. Together, they create a complete plan to lose fat [21].

‍

The possible advantages of combining these two include:

1. Faster fat breakdown

2. Better control over appetite

3. Stronger effects on metabolism

4. Potential to keep weight off long-term

‍

Safety should come first when thinking about this combo. Both AOD 9604 and semaglutide have been tested and shown mostly mild side effects. It's important to talk to a qualified doctor before trying this combination [21].

‍

References

‍

1. Weight Wise Center. Aod 9604 Vs Semaglutide - Weight Wise Weight Loss Center. Weight Wise Weight Loss Center. Published July 2024. Accessed August 16, 2024. https://www.weightwisecenter.com/aod-9604-vs-semaglutide/

‍

2. Rejuv. COMPREHENSIVE REVIEW OF WEIGHT LOSS MEDICATIONS: OZEMPIC, SEMAGLUTIDE, TIRZEPATIDE, MOUNJARO, WEGOVY, AND AOD 9604 PEPTIDE. REJUV. Published September 23, 2023. Accessed August 16, 2024. https://www.rejuvcryo.com/the-science/2023/9/23/comprehensive-review-of-weight-loss-medications-ozempic-semaglutide-tirzepatide-mounjaro-wegovy-and-aod-9604-peptide

‍

3. Hantabal J. Semaglutide vs AOD9604: What Are The Differences? Medisearch.io. Published 2024. Accessed August 16, 2024. https://medisearch.io/blog/semaglutide-vs-aod9604

‍

4. Kommu S, Whitfield P. Semaglutide. PubMed. Published February 11, 2024. Accessed August 16, 2024. https://www.ncbi.nlm.nih.gov/books/NBK603723/

‍

5. Prime Health MD. How Semaglutide Works: Understanding its Mechanisms | PrimeHealth MD. PrimeHealthMD. Published August 24, 2023. Accessed August 16, 2024. https://www.primehealthmd.com/blog/how-semaglutide-works.html

‍

6. Anderson LA. How does semaglutide work for weight loss? Drugs.com. Published March 9, 2024. Accessed August 16, 2024. https://www.drugs.com/medical-answers/semaglutide-work-weight-loss-3573689/

‍

7. Bauder D. AOD 9604 Peptide for Weight Loss: Weight Loss and Vitality: Medical Weight Loss. weightlossandvitality.com. Published 2024. Accessed August 16, 2024. https://www.weightlossandvitality.com/blog/aod-9604-peptide-for-weight-loss

‍

8. Alorfi NM, Algarni AS. Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review. Clinical Pharmacology: Advances and Applications. 2022;Volume 14:61-67. doi: https://doi.org/10.2147/cpaa.s374741

‍

9. Moré MI, Kenley D. Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health. Journal of Endocrinology and Metabolism. 2014;4(3):64-77. doi: https://doi.org/10.14740/jem.v4i3.213

‍

10. Valhalla Vitality. Unlocking the Potential of AOD 9604: A Comprehensive Guide to Its Benefits and Users - Valhalla Vitality. Valhalla Vitality. Published May 22, 2024. Accessed August 16, 2024. https://valhallavitality.com/blog/unlocking-the-potential-of-aod-9604-a-comprehensive-guide-to-its-benefits-and-users

‍

11. Elite Plastic Surgery. Peptide Therapy. eliteplasticsurgeryaz.com. Published 2024. Accessed August 16, 2024. https://eliteplasticsurgeryaz.com/elite-lifestyle/life-longevity/peptide-therapy/

‍

12. Vitality at Focal Point. Focal Point Vitality. Focal Point Vitality Age Management Clinic. Published January 3, 2022. Accessed August 16, 2024. https://focalpointvitality.com/aod-9604-peptide/

‍

13. Kim N, Wang J, Burudpakdee C, et al. Cost-effectiveness analysis of semaglutide 2.4 mg for the treatment of adult patients with overweight and obesity in the United States. Journal of Managed Care & Specialty Pharmacy. 2022;28(7):740-752. doi: https://doi.org/10.18553/jmcp.2022.28.7.740

‍

14. UCLA Health. Semaglutide, also known as Ozempic, for weight loss - what you need to know. uclahealth.org. Published January 12, 2023. Accessed August 16, 2024. https://www.uclahealth.org/news/article/semaglutide-weight-loss-what-you-need-know

‍

15. Anam M, Maharjan S, Amjad Z, et al. Efficacy of Semaglutide in Treating Obesity: A Systematic Review of Randomized Controlled Trials (RCTs). Cureus. 2022;14(12):e32610. doi: https://doi.org/10.7759/cureus.32610

‍

16. Stier H, Vos E, Kenley D. Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism. 2013;3:7-15. doi: https://doi.org/10.4021/jem.v3i1-2.157

‍

17. Taylor, MD, Southwest Family Medical. The Pros and Cons of Semaglutide for Weight Loss - Dr. Taylor. swfamilymedical.com. Published September 7, 2023. Accessed August 16, 2024. https://swfamilymedical.com/pros-cons-semaglutide-for-weight-loss/

‍

18. Garone S. Semaglutide Weight Loss Drugs: Pros, Cons, and Considerations. EverydayHealth.com. Published August 2023. Accessed August 16, 2024. https://www.everydayhealth.com/weight/here-is-when-doctors-say-to-consider-a-weight-loss-drug-like-ozempic/

‍

19. Times Standard. AOD 9604 Peptide Review: 5 Amazing Weight Loss Benefits. times-standard.com. Published November 14, 2023. Accessed August 16, 2024. https://www.times-standard.com/2023/11/14/aod-9604-peptide-review-5-amazing-weight-loss-benefits/

‍

20. ThinMD MedSpa. Ultimate Guide to AOD: The Fat-Burning Peptide - Thin MD Med Spa. Thin MD Med Spa. Published July 3, 2023. Accessed August 16, 2024. https://www.thinmdmedspa.com/ultimate-guide-to-aod-the-fat-burning-peptide/

‍

21. Body Tonic RX. A Synergistic Approach to Accelerated Fat Loss: Combining AOD9604 and Semaglutide. Body Tonic Med Spa. Published August 14, 2023. Accessed August 16, 2024. https://www.mybodytonic.com/single-post/combining-aod9604-and-semaglutide-a-synergistic-approach-to-accelerated-fat-loss

‍

22. Regen Doctors. AOD-9604 Acetate 500 MCG Rapid ODT 30 Melts 1 Daily - Regen Doctors. Regen Doctors. Published August 2, 2024. Accessed August 16, 2024. https://regendoctors.com/products/aod-9604-acetate-500-mcg-rapid-odt-30-melts-1-daily/

‍

23. Limitless Biotech. Buy AOD 9604 Peptide (5mg) | Limitless. Limitless Life Nootropics. Published August 2024. Accessed August 16, 2024. https://www.limitlesslifenootropics.com/product/aod-9604-5mg/

‍

‌Disclaimer: The FDA does not approve compounded medications for safety, quality, or manufacturing. Prescriptions and a medical evaluation are required for certain products. The information provided on this blog is for general informational purposes only. It is not intended as a substitute for professional advice from a qualified healthcare professional and should not be relied upon as personal health advice. The information contained in this blog is not meant to diagnose, treat, cure, or prevent any disease. Readers are advised to consult with a qualified healthcare professional for any medical concerns, including side effects. Use of this blog's information is at your own risk. The blog owner is not responsible for any adverse effects or consequences resulting from the use of any suggestions or information provided in this blog. 

‍